1.14.13.50: pentachlorophenol monooxygenase
This is an abbreviated version!
For detailed information about pentachlorophenol monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.50
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1.14.13.50
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pcp-degrading
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flavobacterium
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sphingobium
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chlorophenolicum
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tetrachlorohydroquinone
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bioremediation
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tetrachlorobenzoquinone
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dehalogenation
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environmental protection
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arthrobacter
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degradation
- 1.14.13.50
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pcp-degrading
- flavobacterium
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sphingobium
- chlorophenolicum
- tetrachlorohydroquinone
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bioremediation
- tetrachlorobenzoquinone
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dehalogenation
- environmental protection
- arthrobacter
- degradation
Reaction
Synonyms
CpsB, dechlorinase, pentachlorophenol, GM610_18120, oxygenase, pentachlorophenol 4-mono-, PCB hydroxylase, PCP 4-monooxygenase, PCP hydroxylase, PCP-4-monooxygenase, PCP-monooxygenase, PCP4MO, PcpB, PcpD, pentachlorophenol 4-mono-oxygenase, pentachlorophenol 4-monooxygenase, pentachlorophenol dechlorinase, pentachlorophenol dehalogenase, pentachlorophenol hydroxylase, pentachlorophenol monooxygenase, pentachlorophenol-4-monooxygenase, Phe4MO, tetrachlorobenzoquinone reductase
ECTree
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Reaction
Reaction on EC 1.14.13.50 - pentachlorophenol monooxygenase
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pentachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O
mechanism
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pentachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O
benzene rings of Phe85, Phe87, Tyr397, as well as Tyr216 and the positive charge of Arg235 are important for activity and stabilization of the active site, reaction mechanism
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pentachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O
direct reduction by NADPH of the flavin at the active site without requirement of intermediate formation
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pentachlorophenol + NADPH + H+ + O2 = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADP+ + chloride + H2O
tetrachlorobenzoquinone reductase PcpD reaction mechanism
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