1.14.13.39: nitric-oxide synthase (NADPH)

This is an abbreviated version!
For detailed information about nitric-oxide synthase (NADPH), go to the full flat file.

Word Map on EC 1.14.13.39

1.14.13.39

artery

necrosis

lipopolysaccharide

l-name

lps

tnf

cardiovascular

cox-2

nitrite

cyclooxygenase-2

vessel

hypertension

cardiac

lps-induced

dismutase

cerebral

vasodilation

nerve

aortic

ischemia

pulmonary

prostaglandin

myocardial

cgmp

ng-nitro-l-arginine

factor-alpha

coronary

acetylcholine

wistar

endothelium-dependent

tnf-alpha

peroxynitrite

contractile

neuroprotective

lps-stimulated

reperfusion

nf-kappab

nitrotyrosine

microglia

interferon-gamma

nitroprusside

ifn-gamma

vasoconstriction

guanylate

vasorelaxation

il-1beta

lipopolysaccharide-induced

erectile

endothelin-1

guanylyl

pharmacology

medicine

Reaction

2 L-arginine + 2 NADPH + 2 H+ + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 NADP⁺ + 2 H2O

Synonyms

bacterial nitric oxide synthase, bacterial nitric-oxide synthase, bNOS, bsNOS, cb-NOS, cytokine inducible NOS, DNOS, e-NOS, EC-NOS, endothelial nitric oxide synthase, endothelial nitric-oxide synthase, endothelial NO synthase, endothelial NOS, endothelium-derived relaxation factor-forming enzyme, endothelium-derived relaxing factor synthase, eNOS, i-NOS, inducible nitric oxide synthase, inducible nitric-oxide synthase, inducible NO synthase, inducible NOS, iNOS, mitochondrial NO synthase, mitochondrial-specific nitric oxide synthase, mtNOS, n-NOS, NADPH diaphorase, NADPH-d, NADPH-diaphorase, NADPHd, neuronal nitric oxide synthase, neuronal nitric-oxide synthase, neuronal NO synthase, neuronal NOS, nicotinamide adenine dinucleotide phosphate-diaphorase, nitric oxid synthase, nitric oxide synthase, nitric oxide synthase-like protein, nitric oxide synthetase, nitric-oxide synthase, nNOS, nNOSalpha, NO synthase, NO synthase type I, NO synthase type II, NO synthase type III, NO-synthase, NOS, NOS I, NOS-2, NOS1, NOS2, NOS3, synthetase, nitric oxide

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.39 nitric-oxide synthase (NADPH)

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Results	in table
52	Activating Compound
4387	AA Sequence
6	Application
1	CAS Registry Number
52	Cloned(Commentary)
373	Cofactor
6	Crystallization (Commentary)
40825	Disease/ Diagnostics
26	Expression
36	General Information
18	General Stability
23	IC50 Value
214	Inhibitors
51	Ki Value [mM]
99	KM Value [mM]
96	Localization
113	Metals/Ions
51	Molecular Weight [Da]
106	Natural Substrates/ Products (Substrates)
2027	Organism
5	Pathway
1313	PDB ID
49	pH Optimum
1	pH Range
4	pH Stability
10	Posttranslational Modification
43	Protein Variants
66	Purification (Commentary)
31	Reaction
3	Reaction Type
220	Reference
1	Renatured (Commentary)
434	Source Tissue
57	Specific Activity [micromol/min/mg]
14	Storage Stability
324	Substrates and Products (Substrate)
68	Subunits
320	Synonyms
1	Systematic Name
72	Temperature Optimum [°C]
3	Temperature Stability [°C]
25	Turnover Number [1/s]

KM Value

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KM Value on EC 1.14.13.39 - nitric-oxide synthase (NADPH)

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0.0008

2',3'-dialdehyde-NADPH

Rattus norvegicus

440196

0.012 - 0.078

adriamycin

5 entries

0.000004

Calmodulin

Bos taurus

440214

0.008 - 0.0084

dichlorophenolindophenol

2 entries

0.0019 - 68.5

L-arginine

40 entries

0.01 - 0.041

menadione

5 entries

0.0073 - 0.055

mitomycin C

5 entries

0.0003 - 0.0041

NADPH

9 entries

0.019 - 0.129

Ngamma-hydroxy-L-arginine

5 entries

0.016

nitroblue tetrazolium

Sus scrofa

440199

0.00002 - 0.114

tetrahydrobiopterin

6 entries

additional information

15 entries