1.14.13.32: albendazole monooxygenase

This is an abbreviated version!
For detailed information about albendazole monooxygenase, go to the full flat file.

Reaction

Synonyms

albendazol sulfoxidase, albendazole oxidase, albendazole sulfoxidase, lancet fluke NADPH-dependent sulphoxidizing enzyme

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.32 albendazole monooxygenase

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Results	in table
2	AA Sequence
1	Application
1	CAS Registry Number
12	Cofactor
3	Inhibitors
6	KM Value [mM]
9	Localization
1	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
7	Organism
37	PDB ID
2	pH Optimum
1	Purification (Commentary)
1	Reaction
4	Reaction Type
7	Reference
9	Source Tissue
5	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
1	Temperature Stability [°C]

Reference

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Reference on EC 1.14.13.32 - albendazole monooxygenase

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285315

Fargetton, X.; Galtier, P.; Delatour, P.

Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes

Vet. Res. Commun.

317-324

1986

Rattus norvegicus, Sus scrofa

3739217

285316

Moroni, P.; Buronfosse, T.; Longin-Sauvageon, C.; Delatour, P.; Benoit, E.

Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes

Drug Metab. Dispos.

160-165

1995

Rattus norvegicus

7736906

658526

Virkel, G.; Lifschitz, A.; Sallovitz, J.; Pis, A.; Lanusse, C.

Comparative hepatic and extrahepatic enantioselective sulfoxidation of albendazole and fenbendazole in sheep and cattle

Drug Metab. Dispos.

536-544

2004

Bos taurus, Ovis aries

15100176

686548

Molina, A.J.; Merino, G.; Prieto, J.G.; Real, R.; Mendoza, G.; Alvarez, A.I.

Absorption and metabolism of albendazole after intestinal ischemia/reperfusion

Eur. J. Pharm. Sci.

16-24

2007

Rattus norvegicus

17350811

701177

Cvilink, V.; Szotakova, B.; Krizova, V.; Lamka, J.; Skalova, L.

Phase I biotransformation of albendazole in lancet fluke (Dicrocoelium dendriticum)

Res. Vet. Sci.

49-55

2009

Dicrocoelium dendriticum

18565554