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1.14.13.32: albendazole monooxygenase

This is an abbreviated version!
For detailed information about albendazole monooxygenase, go to the full flat file.

Reaction

albendazole
+
NADPH
+
H+
+
O2
=
albendazole S-oxide
+
NADP+
+
H2O

Synonyms

albendazol sulfoxidase, albendazole oxidase, albendazole sulfoxidase, lancet fluke NADPH-dependent sulphoxidizing enzyme

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.32 albendazole monooxygenase

KM Value

KM Value on EC 1.14.13.32 - albendazole monooxygenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0047 - 0.0536
albendazole
0.0015
albendazole S-oxide
-
mitochondrial fraction in vitro, pH 7.4, 37°C
additional information
albendazole S-oxide
-
no formation of albendazole sulfone in the microsomal fraction in vitro, pH 7.4, 37°C