1.14.13.22: cyclohexanone monooxygenase

This is an abbreviated version!
For detailed information about cyclohexanone monooxygenase, go to the full flat file.

Reaction

Synonyms

Bpro_556, CAMO, CHMO, ChnB, chnB protein, chnB1 protein, CHXON, CMO, cycloalkaone monooxygenase, cyclohexanone 1, 2-mono-oxygenase, cyclohexanone mono-oxygenase, cyclohexanone monooxygenase, cyclohexanone oxygenase, cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming), oxygenase, cyclohexanone mono-

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.22 cyclohexanone monooxygenase

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Results	in table
3	Activating Compound
667	AA Sequence
23	Application
2	CAS Registry Number
33	Cloned(Commentary)
84	Cofactor
5	Crystallization (Commentary)
3	General Information
1	General Stability
37	Inhibitors
30	kcat/KM [mM/s]
11	Ki Value [mM]
102	KM Value [mM]
6	Localization
1	Metals/Ions
16	Molecular Weight [Da]
51	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
171	Organism
1	Oxidation Stability
5	Pathway
14	PDB ID
15	pH Optimum
4	pH Range
6	pH Stability
59	Protein Variants
32	Purification (Commentary)
23	Reaction
11	Reaction Type
102	Reference
2	Source Tissue
28	Specific Activity [micromol/min/mg]
10	Storage Stability
491	Substrates and Products (Substrate)
16	Subunits
65	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
15	Temperature Stability [°C]
72	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.13.22 - cyclohexanone monooxygenase

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SYSTEMATIC NAME

IUBMB Comments

cyclohexanone,NADPH:oxygen oxidoreductase (lactone-forming)

A flavoprotein (FAD). In the catalytic mechanism of this enzyme, the nucleophilic species that attacks the carbonyl group is a peroxyflavin intermediate that is generated by reaction of the enzyme-bound flavin cofactor with NAD(P)H and oxygen [2]. This enzyme is able to catalyse a wide range of oxidative reactions, including enantioselective Baeyer-Villiger reactions [3], sulfoxidations [4], amine oxidations [5] and epoxidations [6].