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1.14.13.218: 5-methylphenazine-1-carboxylate 1-monooxygenase

This is an abbreviated version!
For detailed information about 5-methylphenazine-1-carboxylate 1-monooxygenase, go to the full flat file.

Reaction

5-methylphenazine-1-carboxylate
+
NADH
+
O2
=
pyocyanin
+
NAD+
+
CO2
+
H2O

Synonyms

PA4217, phzS

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.218 5-methylphenazine-1-carboxylate 1-monooxygenase

Systematic Name

Systematic Name on EC 1.14.13.218 - 5-methylphenazine-1-carboxylate 1-monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
5-methylphenazine-1-carboxylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)
The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in the biosynthesis of pyocyanin, a toxin produced and secreted by the organism. It can also act on phenazine-1-carboxylate, converting it into phenazin-1-ol.