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(-)-epigallocatechin-3-O-gallate
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non-competitive, binds to the enzyme in the proximity of the FAD binding site via formation of three hydrogen bonds
2,4-Dihydroxybenzoate
-
competitive with 4-hydroxybenzoate
3-Chloro-4-hydroxybenzoate
-
mixed-type
4-Aminosalicylate
-
competitive
4-hydroxy-3-nitrobenzoic acid
-
2 mM, 23% inhibition
4-hydroxybutyrate
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92 mM, pH 8, very slight inhibition
4-hydroxyphenylacetic acid
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2 mM, 16% inhibition
4-nitrophenol
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2 mM, 39% inhibition
6-Aminonicotinate
-
competitive
acetate
-
92 mM, pH 8, very slight inhibition
citrate
-
92 mM, pH 8, very slight inhibition
coumaric acid
-
2 mM, 30% inhibition
Cu2+
-
1 mM, moderate inhibition
Fe3+
-
1 mM, moderate inhibition
formate
-
92 mM, pH 8, very slight inhibition
fumarate
-
92 mM, pH 8, very slight inhibition
Hg2+
-
0.1 mM HgCl2, complete inhibition
iodoacetamide
-
reversed by dithiothreitol
Maleate
-
92 mM, pH 8, very slight inhibition
Mn2+
-
1 mM, moderate inhibition
n-dodecyl gallate
-
non-competitive
N-iodosuccinimide
-
reversed by dithiothreitol
NEM
-
0.1 mM, 59% inhibition
o-Iodosobenzoate
-
reversed by dithiothreitol
p-hydroxy-3-iodomethylbenzoate
-
1 mM, irreversible crosslinking to the substrate binding site
Phenylglyoxal
-
pseudo-first order kinetics, incorporation into the substrate-binding site
propionate
-
92 mM, pH 8, very slight inhibition
protocatechuate
-
above 1 mM
Tartrate
-
92 mM, pH 8, very slight inhibition
3,4-dihydroxybenzoate
-
competitive with 4-hydroxybenzoate
3,4-dihydroxybenzoate
-
at high concentration
3-hydroxybenzoate
-
2 mM, 26% inhibition
3-hydroxybenzoate
-
above 1 mM
4-Aminobenzoate
-
competitive
4-Aminobenzoate
-
above 1 mM
4-Fluorobenzoate
-
slight
4-Fluorobenzoate
-
above 1 mM
4-hydroxybenzaldehyde
-
2 mM, 27% inhibition
4-hydroxybenzaldehyde
-
slight
4-hydroxybenzoate
-
above 1 mM
4-hydroxybenzoate
-
above 0.1 mM
4-hydroxybenzoate
-
at high concentrations
4-hydroxybenzoate
-
above 1 mM
4-hydroxybenzoate
-
mixed-type
6-Hydroxynicotinate
-
-
6-Hydroxynicotinate
-
at high concentrations
benzoate
-
competitive with 4-hydroxybenzoate
benzoate
-
2 mM, 48% inhibition
Br-
-
competitive with respect to NADPH; mixed type inhibition with respect to 4-hydroxybenzoate
Br-
-
competitive with respect to NADPH
Cl-
-
non-competitive with NADPH
Cl-
-
50 mM, significant inhibition. No inhibition at 5 mM
Cl-
-
competitive with respect to NADPH; mixed type inhibition with respect to 4-hydroxybenzoate
Cl-
-
competitive with respect to NADPH
Cl-
-
competitive with respect to NADH
CNS-
-
-
CNS-
-
competitive with respect to NADPH
diethyl dicarbonate
-
-
diethyl dicarbonate
-
inhibition of wild-type enzyme, no inhibition of mutant enzyme H162R
F-
-
19 mM, weak
F-
-
competitive with respect to NADPH
I-
-
-
I-
-
competitive with respect to NADPH; mixed type inhibition with respect to 4-hydroxybenzoate
I-
-
competitive with respect to NADPH
N3-
-
-
PCMB
-
0.015 mM, more than 70% inhibition, partially restored by addition of 0.14 M 2-mercaptoethanol
phosphate
-
-
phosphate
-
competitive inhibition
salicylate
-
slight
Zn2+
-
1 mM, moderate inhibition
Zn2+
-
0.2 mM, reversed by 10 mM glutathione
additional information
-
one of the five sulfhydryl groups reacts rapidly and specifically with NEM, without inactivation of the enzyme
-
additional information
-
multisubunit inhibition by ether derivatives
-