1.14.13.196: L-ornithine N5-monooxygenase [NAD(P)H]
This is an abbreviated version!
For detailed information about L-ornithine N5-monooxygenase [NAD(P)H], go to the full flat file.
Reaction
Synonyms
abachelin monooxygenase, AfSidA, AMO, SidA, siderophore A
ECTree
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Cofactor
Cofactor on EC 1.14.13.196 - L-ornithine N5-monooxygenase [NAD(P)H]
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FAD
Q5SE95
FAD-containing enzyme. In the reductive half-reaction, the oxidized FAD bound to the enzyme, is reduced by NADPH. In the oxidative half-reaction, the reduced cofactor reacts with molecular oxygen to form a C4a-hydroperoxyflavin intermediate, which transfers an oxygen atom to ornithine
Q5SE95
8-fold preference in the catalytic efficiency is determined for NADPH compared to NADH
NADH
Q5SE95
accepts reducing equivalents from either NADPH or NADH and displays similar kinetic parameters when using either coenzyme
NADH
-
the enzyme displays very low selectivity for the reduced nicotinamide coenzyme
NADPH
Q5SE95
8-fold preference in the catalytic efficiency is determined for NADPH compared to NADH
NADPH
Q5SE95
accepts reducing equivalents from either NADPH or NADH and displays similar kinetic parameters when using either coenzyme. NADP+, and not NAD+, protects the enzyme from proteolysis
NADPH
-
the enzyme displays very low selectivity for the reduced nicotinamide coenzyme