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1.14.13.195: L-ornithine N5-monooxygenase (NADPH)

This is an abbreviated version!
For detailed information about L-ornithine N5-monooxygenase (NADPH), go to the full flat file.

Word Map on EC 1.14.13.195

Reaction

L-ornithine
+
NADPH
 +
H+
 +
O2
=
N5-hydroxy-L-ornithine
 +
NADP+
 +
H2O

Synonyms

Af-OMO, CchB, flavin-dependent monooxygenase, L-Orn N5-oxygenase, L-ornithine N5-hydroxylase, L-ornithine-Ndelta-oxygenase, monooxygenase EtcB, omega-amino acid monooxygenase, ornithine hydroxylase, ornithine N5-monooxygenase, PsbA, PvdA, SidA, siderophore A

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.195 L-ornithine N5-monooxygenase (NADPH)

Reference

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Reference on EC 1.14.13.195 - L-ornithine N5-monooxygenase (NADPH)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Putignani, L.; Ambrosi, C.; Ascenzi, P.; Visca, P.
Expression of L-ornithine Ndelta-oxygenase (PvdA) in fluorescent Pseudomonas species: an immunochemical and in silico study
Biochem. Biophys. Res. Commun.
313
245-257
2004
Burkholderia cepacia, Pseudomonas putida, Pseudomonas fluorescens, Ralstonia solanacearum, Pseudomonas syringae, Pseudomonas aeruginosa (Q51548), Pseudomonas aeruginosa
Manually annotated by BRENDA team
Meneely, K.M.; Lamb, A.L.
Biochemical characterization of a flavin adenine dinculeotide-dependent monooxygenase, ornithine hydroxylase from Pseudomonas aeruginosa, suggests a novel reaction mechanism
Biochemistry
46
11930-11937
2007
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Meneely, K.M.; Barr, E.W.; Bollinger, J.M. Jr.; Lamb, A.L.
Kinetic mechanism of ornithine hydroxylase (PvdA) from Pseudomonas aeruginosa: substrate triggering of O2 addition but not flavin reduction
Biochemistry
48
4371-4376
2009
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Ambrosi, C.; Leoni, L.; Putignani, L.; Orsi, N.; Visca, P.
Pseudobactin biogenesis, in the plant growth-promoting rhizobacterium Pseudomonas strain B10: Identification and functional analysis of the L-ornithine N5-oxygenase (psbA) gene
J. Bacteriol.
182
6233-6238
2000
Pseudomonas sp. (Q9F8X0), Pseudomonas sp. B10 (Q9F8X0)
Manually annotated by BRENDA team
Ge, L.; Seah, S.Y.K.
Heterologous expression, purification, and characterization of an L-ornithine N5-hydroxylase involved in pyoverdine siderophore biosynthesis in Pseudomonas aeruginosa
J. Bacteriol.
188
7205-7210
2006
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Imperi, F.; Putignani, L.; Tiburzi, F.; Ambrosi, C.; Cipollone, R.; Ascenzi, P.; Visca, P.
Membrane-association determinants of the omega-amino acid monooxygenase PvdA, a pyoverdine biosynthetic enzyme from Pseudomonas aeruginosa
Microbiology
154
2804-2813
2008
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Pohlmann, V.; Marahiel, M.A.
delta-Amino group hydroxylation of L-ornithine during coelichelin biosynthesis
Org. Biomol. Chem.
6
1843-1848
2008
Streptomyces coelicolor, Streptomyces coelicolor A3(2)
Manually annotated by BRENDA team
Robbel, L.; Helmetag, V.; Knappe, T.A.; Marahiel, M.A.
Consecutive enzymatic modification of ornithine generates the hydroxamate moieties of the siderophore erythrochelin
Biochemistry
50
6073-6080
2011
Saccharopolyspora erythraea
Manually annotated by BRENDA team
Romero, E.; Fedkenheuer, M.; Chocklett, S,W.; Qi, J.; Oppenheimer, M.; Sobrado, P.
Dual role of NADP(H) in the reaction of a flavin dependent N-hydroxylating monooxygenase
Biochim. Biophys. Acta
1824
850-857
2012
Aspergillus fumigatus (Q5SE95), Aspergillus fumigatus
Manually annotated by BRENDA team
Guillon, L.; El Mecherki, M.; Altenburger, S.; Graumann, P.L.; Schalk, I.J.
High cellular organization of pyoverdine biosynthesis in Pseudomonas aeruginosa: clustering of PvdA at the old cell pole
Environ. Microbiol.
14
1982-1994
2012
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Frederick, R.E.; Mayfield, J.A.; DuBois, J.L.
Regulated O2 activation in flavin-dependent monooxygenases
J. Am. Chem. Soc.
133
12338-12341
2011
Aspergillus fumigatus
Manually annotated by BRENDA team
Olucha, J.; Meneely, K.M.; Chilton, A.S.; Lamb, A.L.
Two structures of an N-hydroxylating flavoprotein monooxygenase: ornithine hydroxylase from Pseudomonas aeruginosa
J. Biol. Chem.
286
31789-31798
2011
Pseudomonas aeruginosa (Q51548), Pseudomonas aeruginosa
Manually annotated by BRENDA team
Shirey, C.; Badieyan, S.; Sobrado, P.
Role of Ser-257 in the sliding mechanism of NADP(H) in the reaction catalyzed by the Aspergillus fumigatus flavin-dependent ornithine N5-monooxygenase SidA
J. Biol. Chem.
288
32440-32448
2013
Aspergillus fumigatus (Q5SE95), Aspergillus fumigatus
Manually annotated by BRENDA team
Badieyan, S.; Bach, R.; Sobrado, P.
Mechanism of N-hydroxylation catalyzed by flavin-dependent monooxygenases
J. Org. Chem.
80
2139-2147
2015
Aspergillus fumigatus (E9QYP0), Aspergillus fumigatus Af293 (E9QYP0)
Manually annotated by BRENDA team
Robinson, R.; Qureshi, I.A.; Klancher, C.A.; Rodriguez, P.J.; Tanner, J.J.; Sobrado, P.
Contribution to catalysis of ornithine binding residues in ornithine N5-monooxygenase
Arch. Biochem. Biophys.
585
25-31
2015
Aspergillus fumigatus (E9QYP0), Aspergillus fumigatus
Manually annotated by BRENDA team