1.14.13.180: aklavinone 12-hydroxylase
This is an abbreviated version!
For detailed information about aklavinone 12-hydroxylase, go to the full flat file.
Reaction
Synonyms
aklavinone 12-hydroxylase, DnrF, RdmE
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Natural Substrates Products
Natural Substrates Products on EC 1.14.13.180 - aklavinone 12-hydroxylase
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REACTION DIAGRAM
epsilon-rhodomycinone + NADP+ + H2O
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aklavinone + NADPH + H+ + O2
epsilon-rhodomycinone + NADP+ + H2O
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aklavinone + NADPH + H+ + O2
epsilon-rhodomycinone + NADP+ + H2O
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-
-
-
?
aklavinone + NADPH + H+ + O2
epsilon-rhodomycinone + NADP+ + H2O
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the enzyme is involved in the biosynthesis of the anthracycline antibiotic daunorubicin/doxorubicin pathway. During the biosynthesis of L-rhodomycins, RdmE first modifies aklavinone at C-11, and epsilon-rhodomycinone or aklavinone is subsequently glycosylated
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