1.14.13.178: methylxanthine N1-demethylase

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For detailed information about methylxanthine N1-demethylase, go to the full flat file.

Reaction

Synonyms

ndmA, P450-d

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.178 methylxanthine N1-demethylase

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Results	in table
100	AA Sequence
1	Cloned(Commentary)
4	Cofactor
2	General Information
4	kcat/KM [mM/s]
4	KM Value [mM]
1	Localization
2	Metals/Ions
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
9	Organism
9	Pathway
18	PDB ID
2	pH Optimum
2	Purification (Commentary)
9	Reaction
5	Reference
1	Source Tissue
20	Substrates and Products (Substrate)
6	Subunits
5	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.13.178 - methylxanthine N1-demethylase

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caffeine:oxygen oxidoreductase (N1-demethylating)

A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.179, methylxanthine N3-demethylase, and has a 5-fold higher activity with NADH than with NADPH [2]. Also demethylate 1-methylxantine with lower efficiency. Forms part of the degradation pathway of methylxanthines.