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1.14.13.178: methylxanthine N1-demethylase

This is an abbreviated version!
For detailed information about methylxanthine N1-demethylase, go to the full flat file.

Reaction

Caffeine
+
O2
+
NAD(P)H
+
H+
=
Theobromine
+
NAD(P)+
+
H2O
+
formaldehyde

Synonyms

ndmA, P450-d

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.178 methylxanthine N1-demethylase

Natural Substrates Products

Natural Substrates Products on EC 1.14.13.178 - methylxanthine N1-demethylase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
caffeine + O2 + NAD(P)H + H+
theobromine + NAD(P)+ + H2O + formaldehyde
show the reaction diagram
paraxanthine + O2 + NAD(P)H + H+
7-methylxanthine + NAD(P)+ + H2O + formaldehyde
show the reaction diagram
theophylline + O2 + NAD(P)H + H+
3-methylxanthine + NAD(P)+ + H2O + formaldehyde
show the reaction diagram
the enzyme forms part of the degradation pathway of methylxanthines. The activity of the enzyme is dependent on electron transfer from NADH via a redox-center-dense Rieske reductase, NdmD
-
-
?
theophylline + O2 + NADPH + H+
3-methylxanthine + NADP+ + H2O + formaldehyde
show the reaction diagram
-
i.e. 1,3-dimethylxanthine
-
-
?