1.14.13.163: 6-hydroxy-3-succinoylpyridine 3-monooxygenase
This is an abbreviated version!
For detailed information about 6-hydroxy-3-succinoylpyridine 3-monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.163
-
1.14.13.163
-
pyrrolidine
-
putida
-
2,5-dihydroxypyridine
-
tumefaciens
-
agrobacterium
-
arthrobacter
-
fad-binding
-
ochrobactrum
-
wastes
-
synthesis
-
nicotine-degrading
-
flavoprotein
- 1.14.13.163
- pyrrolidine
- putida
- 2,5-dihydroxypyridine
- tumefaciens
-
agrobacterium
- arthrobacter
-
fad-binding
-
ochrobactrum
- wastes
- synthesis
-
nicotine-degrading
- flavoprotein
Reaction
+ 2 NADH + 2 H+ + = + + 2 NAD+ +
Synonyms
6-hydroxy-3-succinoyl-pyridine 3-monooxygenase, 6-hydroxy-3-succinoylpyridine hydroxylase, AWN88_01205, Hsh, HSP 3-monooxygenase, HSP hydroxylase, HSP monooxygenase, hspA, hspB, HSPH, HSPHZZ, NADH-dependent HSP hydroxylase, NIC, nicotine hydroxylase, VppD, W7K_00670
ECTree
Advanced search results
Reaction
Reaction on EC 1.14.13.163 - 6-hydroxy-3-succinoylpyridine 3-monooxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 = 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 = 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
-
-
-
-
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 = 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
catalytic mechanism, overview. In contrast to conclusions reported previously, the second product of the HspB reaction is shown to be succinate, with isotope labeling experiments providing direct evidence that the newly introduced oxygen atom of succinate is derived from H2O. Reduced HspB reacts with oxygen to form a C(4a)-(hydro)peroxyflavin intermediate before it is converted to the oxidized flavoenzyme species. The formed C(4a)-hydroperoxyflavin intermediate reacts with HSP to form an intermediate that is hydrolyzed to the products 2,5-dihydroxypyridine and succinate
-
4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H+ + O2 = 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD+ + H2O
catalytic mechanism, overview. In contrast to conclusions reported previously, the second product of the HspB reaction is shown to be succinate, with isotope labeling experiments providing direct evidence that the newly introduced oxygen atom of succinate is derived from H2O. Reduced HspB reacts with oxygen to form a C(4a)-(hydro)peroxyflavin intermediate before it is converted to the oxidized flavoenzyme species. The formed C(4a)-hydroperoxyflavin intermediate reacts with HSP to form an intermediate that is hydrolyzed to the products 2,5-dihydroxypyridine and succinate
-
-