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1.14.13.148: trimethylamine monooxygenase

This is an abbreviated version!
For detailed information about trimethylamine monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.148

Reaction

N,N,N-trimethylamine
+
NADPH
 +
H+
 +
O2
=
N,N,N-trimethylamine N-oxide
 +
NADP+
 +
H2O

Synonyms

dimethyl sulfoxide/trimethylamine N-oxide reductase, EC 1.14.13.8, FAD-containing monooxygenase, flavin containing monooxygenase 3, flavin monooxygenase 3, flavin-containing monooxygenase, flavin-containing monooxygenase 3, FMO, FMO3, FMO4, PB7211, TMA monooxygenase, TMA N-oxygenase, TMM

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.148 trimethylamine monooxygenase

Expression

Expression on EC 1.14.13.148 - trimethylamine monooxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
5-aza-2'-deoxycytidine at 0.001 mM and 0.0025 mM results in 6.6fold and 9.2fold increases in FMO3 mRNA levels, respectively. HNF4alpha transient expression results in a 3.1fold increase in FMO3 mRNA levels. Co-transfection of HepG2 cells with the CCAAT/enhancer-binding protein beta expression vector and the pRNH694 reporter construct results in a dose-dependent increase in FMO3 promoter activity with a maximal 2fold increase using 0.001 mg of expression
-
no changes in relative FMO3 mRNA levels are observed with 50 nM trichostatin A
-
the enzyme is absent during growth on methanol
-
the enzyme is highly expressed in N,N,N-trimethylamine-grown Methylocella silvestris
-