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1.14.13.114: 6-hydroxynicotinate 3-monooxygenase

This is an abbreviated version!
For detailed information about 6-hydroxynicotinate 3-monooxygenase, go to the full flat file.

Reaction

6-Hydroxynicotinate
+
NADH
+
H+
+
O2
=
2,5-dihydroxypyridine
+
NAD+
+
H2O
+
CO2

Synonyms

6-hydroxynicotinic acid 3-monooxygenase, 6HNA monooxygenase, BB1770, BbNicC, NicC, PpNicC

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.114 6-hydroxynicotinate 3-monooxygenase

Reference

Reference on EC 1.14.13.114 - 6-hydroxynicotinate 3-monooxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nakano, H.; Wieser, M.; Hurh, B.; Kawai, T.; Yoshida, T.; Yamane, T.; Nagasawa, T.
Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5
Eur. J. Biochem.
260
120-126
1999
Pseudomonas fluorescens, Pseudomonas fluorescens TN5
Manually annotated by BRENDA team
Jimenez, J.; Canales, A.; Jimenez-Barbero, J.; Ginalski, K.; Rychlewski, L.; Garcia, J.; Diaz, E.
Deciphering the genetic determinants for aerobic nicotinic acid degradation: The nic cluster from Pseudomonas putida KT2440
Proc. Natl. Acad. Sci. USA
105
11329-11334
2008
Pseudomonas putida, Pseudomonas putida KT 2240
Manually annotated by BRENDA team
Hicks, K.; Yuen, M.; Zhen, W.; Gerwig, T.; Story, R.; Kopp, M.; Snider, M.
Structural and biochemical characterization of 6-hydroxynicotinic acid 3-monooxygenase, a novel decarboxylative hydroxylase involved in aerobic nicotinate degradation
Biochemistry
55
3432-3446
2016
Neobacillus niacini, Bordetella bronchiseptica (A0A0H3LLR0), Pseudomonas putida (Q88FY2), Bordetella bronchiseptica ATCC BAA-588 / NCTC 13252 / RB50 (A0A0H3LLR0)
Manually annotated by BRENDA team
Nakamoto, K.D.; Perkins, S.W.; Campbell, R.G.; Bauerle, M.R.; Gerwig, T.J.; Gerislioglu, S.; Wesdemiotis, C.; Anderson, M.A.; Hicks, K.A.; Snider, M.J.
Mechanism of 6-hydroxynicotinate 3-monooxygenase, a flavin-dependent decarboxylative hydroxylase involved in bacterial nicotinic acid degradation
Biochemistry
58
1751-1763
2019
Bordetella bronchiseptica (A0A0H3LKL4), Bordetella bronchiseptica ATCC BAA-588 (A0A0H3LKL4), Bordetella bronchiseptica RB50 (A0A0H3LKL4), Bordetella bronchiseptica RB50, Bordetella bronchiseptica NCTC 13252 (A0A0H3LKL4)
Manually annotated by BRENDA team