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1.14.13.111: methanesulfonate monooxygenase (NADH)

This is an abbreviated version!
For detailed information about methanesulfonate monooxygenase (NADH), go to the full flat file.

Word Map on EC 1.14.13.111

Reaction

methanesulfonate
+
NADH
+
H+
+
O2
=
formaldehyde
+
NAD+
+
sulfite
+
H2O

Synonyms

EC 1.14.14.6, methanesulfonate monooxygenase, methanesulfonic acid monooxygenase, MSA monooxygenase, MSAMO, Msm, MsmA

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.111 methanesulfonate monooxygenase (NADH)

Systematic Name

Systematic Name on EC 1.14.13.111 - methanesulfonate monooxygenase (NADH)

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SYSTEMATIC NAME
IUBMB Comments
methanesulfonate,NADH:oxygen oxidoreductase
A flavoprotein. Methanesulfonate is the simplest of the sulfonates and is a substrate for the growth of certain methylotrophic microorganisms. Compared with EC 1.14.14.5, alkanesulfonate monooxygenase, this enzyme has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methanesulfonate to butanesulfonate) and excludes all larger molecules, such as arylsulfonates [1]. The enzyme from the bacterium Methylosulfonomonas methylovora is a multicomponent system comprising a hydroxylase, a reductase (MsmD) and a ferredoxin (MsmC). The hydroxylase has both large (MsmA) and small (MsmB) subunits, with each large subunit containing a Rieske-type [2Fe-2S] cluster. cf. EC 1.14.14.34, methanesulfonate monooxygenase (FMNH2).