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1.14.13.101: senecionine N-oxygenase

This is an abbreviated version!
For detailed information about senecionine N-oxygenase, go to the full flat file.

Reaction

senecionine
+
NADPH
+
H+
+
O2
=
senecionine N-oxide
+
NADP+
+
H2O

Synonyms

flavin-dependent monooxygenase, fmoa, GgPNO, oxygenase, senecionine N-, PA N-oxygenase, PNO, pyrrolizidine alkaloid N-oxygenase, senecionine monooxygenase (N-oxide-forming), senecionine N-oxygenase, SNO, TjSNO, ZvFMOa, ZvPNO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.101 senecionine N-oxygenase

Reference

Reference on EC 1.14.13.101 - senecionine N-oxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lindigkeit, R.; Biller, A.; Buch, M.; Schiebel, H.M.; Boppre, M.; Hartmann, T.
The two faces of pyrrolizidine alkaloids: the role of the tertiary amine and its N-oxide in chemical defense of insects with aquired alkaloids
Eur. J. Biochem.
245
626-636
1997
Arctia caja, Tyria jacobaeae, no activity in Spodoptera littoralis, Creatonotos transiens, Callimorpha dominula, Arctia intercalaris, Amerila phaedra, Idea leuconoe, Zonocerus variegatus
Manually annotated by BRENDA team
Naumann, C.; Hartmann, T.; Ober, D.
Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-defended arctiid moth Tyria jacobaeae
Proc. natl. Acad. Sci. USA
99
6085-6090
2002
Tyria jacobaeae (Q8MP06), Tyria jacobaeae
Manually annotated by BRENDA team
Chang, A.; Hartmann, T.
Solubilization and characterization of a senecionine N-oxygenase from Crotalaria scassellatii seedlings
Phytochemistry
49
1859-1866
1998
Crotalaria scassellatii
-
Manually annotated by BRENDA team
Sehlmeyer, S.; Wang, L.; Langel, D.; Heckel, D.G.; Mohagheghi, H.; Petschenka, G.; Ober, D.
Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (lepidoptera)
PLoS ONE
5
e10435
2010
Apantesis nevadensis geneura (D6CHF2), Apantesis nevadensis geneura, Tyria jacobaeae (Q8MP06), Tyria jacobaeae
Manually annotated by BRENDA team
Wang, L.; Beuerle, T.; Timbilla, J.; Ober, D.
Independent recruitment of a flavin-dependent monooxygenase for safe accumulation of sequestered pyrrolizidine alkaloids in grasshoppers and moths
PLoS ONE
7
e31796
2012
Zonocerus variegatus
Manually annotated by BRENDA team
Kubitza, C.; Faust, A.; Gutt, M.; Gaeth, L.; Ober, D.; Scheidig, A.J.
Crystal structure of pyrrolizidine alkaloid N-oxygenase from the grasshopper Zonocerus variegatus
Acta Crystallogr. Sect. D
74
422-432
2018
Zonocerus variegatus (L0N8F3), Zonocerus variegatus (L0N8S9), Zonocerus variegatus
Manually annotated by BRENDA team