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1-hydroxy-2-naphthoate + NADH + 2 H+ + O2
?
-
137% of the activity with salicylate
-
-
?
1-hydroxy-2-naphthoate + NADH + H+ + O2
?
1-hydroxy-2-naphthoate + NADH + O2
1,2-dihydroxynaphthalene + CO2 + H2O + NAD+
-
-
-
-
?
2,3-dihydroxybenzoate + NADH + 2 H+ + O2
pyrogallol + NAD+ + H2O + CO2
2,3-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane + NADH
NO2- + N2O + formate + NH4+
-
the enzyme catalyzes two oxygen-sensitive single-electron transfer steps necessary to release two nitrite ions from 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane and this is followed by the secondary decomposition of this energetic chemical
N2O is abiotically produced from NO2-NH2
-
?
2,4-dihydroxybenzoate + NAD(P)H + O2
benzene-1,2,4-triol + CO2 + H2O + NAD(P)+
-
-
-
?
2,4-dihydroxybenzoate + NADH + 2 H+ + O2
1,2,4-trihydroxybenzene + NAD+ + H2O + CO2
-
91% of the activity with salicylate
-
-
?
2,4-dihydroxybenzoate + NADPH + H+ + O2
benzene-1,2,4-triol + NAD+ + H2O + CO2
-
-
-
-
r
2,5-dihydroxybenzoate + NADH + O2
benzene-1,2,5-triol + CO2 + H2O + NAD+
2,5-dihydroxybenzoic acid + NADH + H+ + O2
2,5-dihydroxyphenol + NAD+ + H2O + CO2
146% activity compared to salicylate
-
-
?
2,6-dihydroxybenzoate + NADH + 2 H+ + O2
1,2,3-trihydroxybenzene + NAD+ + H2O + CO2
-
70% of the activity with salicylate
-
-
?
2,6-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
2-hydroxy-1-naphthoate + NADH + 2 H+ + O2
?
-
160% of the activity with salicylate
-
-
?
3,5-dinitrosalicylate + NADH + O2
? + NAD+ + H2O + CO2
3-aminosalicylate + NADH + H+ + O2
3-aminobenzene-1,2-diol + NAD+ + H2O + CO2
3-chlorosalicylate + NADH + H+ + O2
3-chlorobenzene-1,2-diol + NAD+ + H2O + CO2
3-chlorosalicylate + NADH + H+ + O2
3-chlorocatechol + NAD+ + H2O + CO2
-
-
-
?
3-methylsalicylate + NADH + 2 H+ + O2
3-methylcatechol + NAD+ + H2O + CO2
3-methylsalicylate + NADH + H+ + O2
3-methylbenzene-1,2-diol + NAD+ + H2O + CO2
3-methylsalicylate + NADH + H+ + O2
3-methylcatechol + NAD+ + H2O + CO2
-
-
-
?
3-methylsalicylate + NADH + O2
1,2-dihydroxy-3-methylbenzene + CO2 + NAD+ + H2O
3-methylsalicylate + NADH + O2
1,2-dihydroxy-3-methylbenzene + NAD+ + H2O + CO2
4-(3-benzothiazol-2-yl-4-cyano-2-oxo-2H-chromen-7-yloxymethyl)-2-hydroxy-benzoic acid + O2 + NADH + 2 H+
?
-
i.e. SHLF, two-step synthesis of a long-wavelength latent fluorogenic substrate SHLF. In the presence of NADH and under aerobic conditions, SHL catalyzes the decarboxylative hydroxylation of SHLF followed by a quinonemethide-type rearrangement reaction concomitant with the ejection of a fluorescence coumarin 2, which is spontaneous and irreversible at physiological temperatures in aqueous media. The fluorescence signal generated by this process is specific and, in the near red spectral region with an emission maximum at 595 nm, is suppressed by salicylic acid
-
-
?
4-aminosalicylate + NADH + 2 H+ + O2
4-aminocatechol + NAD+ + H2O + CO2
4-aminosalicylate + NADH + H+ + O2
4-aminobenzene-1,2-diol + NAD+ + H2O + CO2
4-aminosalicylate + NADH + O2
4-aminocatechol + CO2 + NAD+ + H2O
4-chlorosalicylate + NADH + H+ + O2
4-chlorobenzene-1,2-diol + NAD+ + H2O + CO2
4-chlorosalicylate + NADH + H+ + O2
4-chlorocatechol + NAD+ + H2O + CO2
-
-
-
?
4-chlorosalicylate + NADH + O2
1,2-dihydroxy-4-chlorobenzene + CO2 + NAD+ + H2O
4-chlorosalicylate + NADH + O2
4-chlorocatechol + NAD+ + H2O + CO2
-
-
-
-
?
4-methylsalicylate + NADH + 2 H+ + O2
4-methylcatechol + NAD+ + H2O + CO2
4-methylsalicylate + NADH + H+ + O2
4-methylbenzene-1,2-diol + NAD+ + H2O + CO2
4-methylsalicylate + NADH + O2
1,2-dihydroxy-4-methylbenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-aminosalicylate + NADH + 2 H+ + O2
5-aminocatechol + NAD+ + H2O + CO2
5-aminosalicylate + NADH + H+ + O2
5-aminobenzene-1,2-diol + NAD+ + H2O + CO2
5-aminosalicylate + NADH + O2
5-aminocatechol + CO2 + NAD+ + H2O
-
-
-
-
?
5-chlorosalicylate + NADH + 2 H+ + O2
4-chlorocatechol + NAD+ + H2O + CO2
-
46% of the activity with salicylate
-
-
?
5-chlorosalicylate + NADH + H+ + O2
5-chlorobenzene-1,2-diol + NAD+ + H2O + CO2
5-chlorosalicylate + NADH + H+ + O2
5-chlorocatechol + NAD+ + H2O + CO2
-
-
-
?
5-chlorosalicylate + NADH + O2
1,2-dihydroxy-5-chlorobenzene + CO2 + NAD+ + H2O
5-chlorosalicylate + NADH + O2
1,2-dihydroxy-5-chlorobenzene + NAD+ + H2O + CO2
5-fluorosalicylate + NADH + O2
1,2-dihydroxy-5-fluorobenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-hydroxysalicylate + NADH + H+ + O2
2,5-dihydroxyphenol + NAD+ + H2O + CO2
5-methoxysalicylate + NADH + O2
1,2-dihydroxy-5-methoxybenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-methylsalicylate + NADH + 2 H+ + O2
4-methylcatechol + NAD+ + H2O + CO2
-
68.5% of the activity with salicylate
-
-
?
5-methylsalicylate + NADH + 2 H+ + O2
5-methylcatechol + NAD+ + H2O + CO2
5-methylsalicylate + NADH + H+ + O2
1,2-dihydroxy-5-methylbenzene + CO2 + NAD+ + H2O
5-methylsalicylate + NADH + H+ + O2
4-methylbenzene-1,2-diol + NAD+ + H2O + CO2
5-nitrosalicylate + NADH + 2 H+ + O2
4-nitrocatechol + NAD+ + H2O + CO2
-
32% of the activity with salicylate
-
-
?
anthranilate + NADH + 2 H+ + O2
2-aminophenol + NAD+ + H2O + CO2
-
67% of the activity with salicylate
-
-
?
aspirin + NADH + O2
? + NAD+ + H2O + CO2
-
-
-
-
?
gentisate + NADH + 2 H+ + O2
?
-
99% of the activity with salicylate
-
-
?
gentisate + NADH + 2 H+ + O2
hydroxyquinol + NAD+ + H2O + CO2
-
93% activity compared to salicylate
-
-
?
m-hydroxybenzoate + NADH + O2
1,3-dihydroxybenzene + CO2 + NAD+ + H2O
-
6% of the reaction with salicylate
-
-
?
o-iodophenol + NADH + O2
catechol + iodide + NAD+
-
-
-
-
?
o-nitrophenol + NADH + O2
catechol + nitrite + NAD+
p-aminosalicylate + NADH + O2
1,2-dihydroxy-4-aminobenzene + NAD+ + CO2 + H2O
salicylaldehyde + NADH + O2
catechol + formate + NAD+
-
mechanism
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
salicylate + O2 + NADH + 2 H+
catechol + CO2 + H2O + NAD+
salicylate + O2 + NADPH + 2 H+
catechol + CO2 + H2O + NADP+
sulfosalicylate + NADH + O2
? + NAD+ + H2O + CO2
-
-
-
-
?
additional information
?
-
1-hydroxy-2-naphthoate + NADH + H+ + O2
?
-
25% activity compared to salicylate
-
-
?
1-hydroxy-2-naphthoate + NADH + H+ + O2
?
-
25% activity compared to salicylate
-
-
?
1-hydroxy-2-naphthoate + NADH + H+ + O2
?
-
83% activity compared to salicylate
-
-
?
1-hydroxy-2-naphthoate + NADH + H+ + O2
?
-
83% activity compared to salicylate
-
-
?
2,3-dihydroxybenzoate + NADH + 2 H+ + O2
pyrogallol + NAD+ + H2O + CO2
-
82% activity compared to salicylate
-
-
?
2,3-dihydroxybenzoate + NADH + 2 H+ + O2
pyrogallol + NAD+ + H2O + CO2
-
82% activity compared to salicylate
-
-
?
2,3-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
-
-
-
?
2,3-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
-
-
-
-
?
2,3-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
-
-
-
-
?
2,3-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
-
-
-
?
2,3-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
-
-
-
-
?
2,5-dihydroxybenzoate + NADH + O2
benzene-1,2,5-triol + CO2 + H2O + NAD+
-
or NADPH
-
?
2,5-dihydroxybenzoate + NADH + O2
benzene-1,2,5-triol + CO2 + H2O + NAD+
-
-
-
-
?
2,5-dihydroxybenzoate + NADH + O2
benzene-1,2,5-triol + CO2 + H2O + NAD+
-
-
-
-
?
2,5-dihydroxybenzoate + NADH + O2
benzene-1,2,5-triol + CO2 + H2O + NAD+
-
-
-
-
?
2,6-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
-
-
-
?
2,6-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
-
-
-
-
?
2,6-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
-
-
-
-
?
2,6-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
-
-
-
?
2,6-dihydroxybenzoate + NADH + O2
pyrogallol + CO2 + H2O + NAD+
-
-
-
-
?
3,5-dinitrosalicylate + NADH + O2
? + NAD+ + H2O + CO2
-
-
-
-
?
3,5-dinitrosalicylate + NADH + O2
? + NAD+ + H2O + CO2
-
-
-
-
?
3-aminosalicylate + NADH + H+ + O2
3-aminobenzene-1,2-diol + NAD+ + H2O + CO2
-
11% activity compared to salicylate
-
-
?
3-aminosalicylate + NADH + H+ + O2
3-aminobenzene-1,2-diol + NAD+ + H2O + CO2
-
11% activity compared to salicylate
-
-
?
3-aminosalicylate + NADH + H+ + O2
3-aminobenzene-1,2-diol + NAD+ + H2O + CO2
-
62% activity compared to salicylate
-
-
?
3-aminosalicylate + NADH + H+ + O2
3-aminobenzene-1,2-diol + NAD+ + H2O + CO2
-
62% activity compared to salicylate
-
-
?
3-chlorosalicylate + NADH + H+ + O2
3-chlorobenzene-1,2-diol + NAD+ + H2O + CO2
-
15% activity compared to salicylate
-
-
?
3-chlorosalicylate + NADH + H+ + O2
3-chlorobenzene-1,2-diol + NAD+ + H2O + CO2
-
15% activity compared to salicylate
-
-
?
3-chlorosalicylate + NADH + H+ + O2
3-chlorobenzene-1,2-diol + NAD+ + H2O + CO2
-
23% activity compared to salicylate
-
-
?
3-chlorosalicylate + NADH + H+ + O2
3-chlorobenzene-1,2-diol + NAD+ + H2O + CO2
-
23% activity compared to salicylate
-
-
?
3-methylsalicylate + NADH + 2 H+ + O2
3-methylcatechol + NAD+ + H2O + CO2
-
-
-
r
3-methylsalicylate + NADH + 2 H+ + O2
3-methylcatechol + NAD+ + H2O + CO2
-
-
-
r
3-methylsalicylate + NADH + 2 H+ + O2
3-methylcatechol + NAD+ + H2O + CO2
-
76% of the activity with salicylate
-
-
?
3-methylsalicylate + NADH + H+ + O2
3-methylbenzene-1,2-diol + NAD+ + H2O + CO2
-
47% activity compared to salicylate
-
-
?
3-methylsalicylate + NADH + H+ + O2
3-methylbenzene-1,2-diol + NAD+ + H2O + CO2
-
86% activity compared to salicylate
-
-
?
3-methylsalicylate + NADH + O2
1,2-dihydroxy-3-methylbenzene + CO2 + NAD+ + H2O
-
-
-
-
?
3-methylsalicylate + NADH + O2
1,2-dihydroxy-3-methylbenzene + CO2 + NAD+ + H2O
-
-
-
-
?
3-methylsalicylate + NADH + O2
1,2-dihydroxy-3-methylbenzene + NAD+ + H2O + CO2
-
-
-
-
?
3-methylsalicylate + NADH + O2
1,2-dihydroxy-3-methylbenzene + NAD+ + H2O + CO2
-
-
-
-
?
4-aminosalicylate + NADH + 2 H+ + O2
4-aminocatechol + NAD+ + H2O + CO2
-
72% activity compared to salicylate
-
-
?
4-aminosalicylate + NADH + 2 H+ + O2
4-aminocatechol + NAD+ + H2O + CO2
-
72% activity compared to salicylate
-
-
?
4-aminosalicylate + NADH + H+ + O2
4-aminobenzene-1,2-diol + NAD+ + H2O + CO2
-
94% activity compared to salicylate
-
-
?
4-aminosalicylate + NADH + H+ + O2
4-aminobenzene-1,2-diol + NAD+ + H2O + CO2
-
130% activity compared to salicylate
-
-
?
4-aminosalicylate + NADH + O2
4-aminocatechol + CO2 + NAD+ + H2O
-
-
-
-
?
4-aminosalicylate + NADH + O2
4-aminocatechol + CO2 + NAD+ + H2O
-
-
-
-
?
4-aminosalicylate + NADH + O2
4-aminocatechol + CO2 + NAD+ + H2O
-
-
-
-
?
4-chlorosalicylate + NADH + H+ + O2
4-chlorobenzene-1,2-diol + NAD+ + H2O + CO2
-
43% activity compared to salicylate
-
-
?
4-chlorosalicylate + NADH + H+ + O2
4-chlorobenzene-1,2-diol + NAD+ + H2O + CO2
-
78% activity compared to salicylate
-
-
?
4-chlorosalicylate + NADH + O2
1,2-dihydroxy-4-chlorobenzene + CO2 + NAD+ + H2O
-
-
-
-
?
4-chlorosalicylate + NADH + O2
1,2-dihydroxy-4-chlorobenzene + CO2 + NAD+ + H2O
-
-
-
-
?
4-chlorosalicylate + NADH + O2
1,2-dihydroxy-4-chlorobenzene + CO2 + NAD+ + H2O
-
-
-
-
?
4-chlorosalicylate + NADH + O2
1,2-dihydroxy-4-chlorobenzene + CO2 + NAD+ + H2O
-
-
-
-
?
4-methylsalicylate + NADH + 2 H+ + O2
4-methylcatechol + NAD+ + H2O + CO2
-
-
-
?
4-methylsalicylate + NADH + 2 H+ + O2
4-methylcatechol + NAD+ + H2O + CO2
-
108% of the activity with salicylate
-
-
?
4-methylsalicylate + NADH + H+ + O2
4-methylbenzene-1,2-diol + NAD+ + H2O + CO2
-
166% activity compared to salicylate
-
-
?
4-methylsalicylate + NADH + H+ + O2
4-methylbenzene-1,2-diol + NAD+ + H2O + CO2
-
164% activity compared to salicylate
-
-
?
5-aminosalicylate + NADH + 2 H+ + O2
5-aminocatechol + NAD+ + H2O + CO2
-
-
-
r
5-aminosalicylate + NADH + 2 H+ + O2
5-aminocatechol + NAD+ + H2O + CO2
-
-
-
r
5-aminosalicylate + NADH + H+ + O2
5-aminobenzene-1,2-diol + NAD+ + H2O + CO2
-
80% activity compared to salicylate
-
-
?
5-aminosalicylate + NADH + H+ + O2
5-aminobenzene-1,2-diol + NAD+ + H2O + CO2
-
50% activity compared to salicylate
-
-
?
5-chlorosalicylate + NADH + H+ + O2
5-chlorobenzene-1,2-diol + NAD+ + H2O + CO2
-
14% activity compared to salicylate
-
-
?
5-chlorosalicylate + NADH + H+ + O2
5-chlorobenzene-1,2-diol + NAD+ + H2O + CO2
-
18% activity compared to salicylate
-
-
?
5-chlorosalicylate + NADH + O2
1,2-dihydroxy-5-chlorobenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-chlorosalicylate + NADH + O2
1,2-dihydroxy-5-chlorobenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-chlorosalicylate + NADH + O2
1,2-dihydroxy-5-chlorobenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-chlorosalicylate + NADH + O2
1,2-dihydroxy-5-chlorobenzene + NAD+ + H2O + CO2
-
-
-
-
?
5-chlorosalicylate + NADH + O2
1,2-dihydroxy-5-chlorobenzene + NAD+ + H2O + CO2
-
-
-
-
?
5-hydroxysalicylate + NADH + H+ + O2
2,5-dihydroxyphenol + NAD+ + H2O + CO2
-
132% activity compared to salicylate
-
-
?
5-hydroxysalicylate + NADH + H+ + O2
2,5-dihydroxyphenol + NAD+ + H2O + CO2
-
84% activity compared to salicylate
-
-
?
5-methylsalicylate + NADH + 2 H+ + O2
5-methylcatechol + NAD+ + H2O + CO2
-
-
-
r
5-methylsalicylate + NADH + 2 H+ + O2
5-methylcatechol + NAD+ + H2O + CO2
-
-
-
r
5-methylsalicylate + NADH + 2 H+ + O2
5-methylcatechol + NAD+ + H2O + CO2
-
-
-
?
5-methylsalicylate + NADH + H+ + O2
1,2-dihydroxy-5-methylbenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-methylsalicylate + NADH + H+ + O2
1,2-dihydroxy-5-methylbenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-methylsalicylate + NADH + H+ + O2
1,2-dihydroxy-5-methylbenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-methylsalicylate + NADH + H+ + O2
1,2-dihydroxy-5-methylbenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-methylsalicylate + NADH + H+ + O2
1,2-dihydroxy-5-methylbenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-methylsalicylate + NADH + H+ + O2
1,2-dihydroxy-5-methylbenzene + CO2 + NAD+ + H2O
-
-
-
-
?
5-methylsalicylate + NADH + H+ + O2
4-methylbenzene-1,2-diol + NAD+ + H2O + CO2
-
81% activity compared to salicylate
-
-
?
5-methylsalicylate + NADH + H+ + O2
4-methylbenzene-1,2-diol + NAD+ + H2O + CO2
-
40% activity compared to salicylate
-
-
?
o-nitrophenol + NADH + O2
catechol + nitrite + NAD+
-
-
-
-
?
o-nitrophenol + NADH + O2
catechol + nitrite + NAD+
-
-
-
-
?
p-aminosalicylate + NADH + O2
1,2-dihydroxy-4-aminobenzene + NAD+ + CO2 + H2O
-
-
-
-
?
p-aminosalicylate + NADH + O2
1,2-dihydroxy-4-aminobenzene + NAD+ + CO2 + H2O
-
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
best substrate, almost complete conversion
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
best substrate, almost complete conversion
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
r
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
r
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + 2 H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
100% activity
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
bismuth salt of salicylate
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
bismuth salt of salicylate
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
100% activity
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
100% activity
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
389997, 389998, 390001, 390002, 390003, 390004, 390006, 390007, 390009, 390010, 390013, 390014, 390015, 390016, 390017, 741666, 741825, 742130 -
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
100% activity
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
100% activity
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + NADH + H+ + O2
catechol + NAD+ + H2O + CO2
-
-
-
-
?
salicylate + O2 + NADH + 2 H+
catechol + CO2 + H2O + NAD+
-
-
-
-
?
salicylate + O2 + NADH + 2 H+
catechol + CO2 + H2O + NAD+
-
-
-
-
?
salicylate + O2 + NADH + 2 H+
catechol + CO2 + H2O + NAD+
-
-
-
-
?
salicylate + O2 + NADPH + 2 H+
catechol + CO2 + H2O + NADP+
-
-
-
-
?
salicylate + O2 + NADPH + 2 H+
catechol + CO2 + H2O + NADP+
-
-
-
-
?
additional information
?
-
terbinafine resistance mediated by salicylate 1-monooxygenase. Terbinafine, which has a naphthalene nucleus in its chemical structure, may be a substrate for a salicylate-like part of an aromatic compound degradation pathway in Aspergillus nidulans
-
-
?
additional information
?
-
-
terbinafine resistance mediated by salicylate 1-monooxygenase. Terbinafine, which has a naphthalene nucleus in its chemical structure, may be a substrate for a salicylate-like part of an aromatic compound degradation pathway in Aspergillus nidulans
-
-
?
additional information
?
-
-
incubation of salicylic acid by a combination of cell extracts from the shyA with the crcA or the hqdA overexpression strains results in the formation of cis,cis-muconic acid, demonstrating that the combination of these enzymes is sufficient for this biochemical conversion. The conversion is highly efficient. No activity with protocatechuate, vanillate, syringate, 3-hydroxybenzoate, 4-hydroxybenzoate, and benzoate. ShyA shows activity on o-hydroxylated benzoic acids, such as 4-aminosalicylic acid, 2,3-dihydroxybenzoic acid, and gentisic acid, but not on benzoic acid derivatives that are not o-hydroxylated. The enzyme also exhibits NADH oxidase activity besides the more rapid hydroxylase activity
-
-
-
additional information
?
-
-
incubation of salicylic acid by a combination of cell extracts from the shyA with the crcA or the hqdA overexpression strains results in the formation of cis,cis-muconic acid, demonstrating that the combination of these enzymes is sufficient for this biochemical conversion. The conversion is highly efficient. No activity with protocatechuate, vanillate, syringate, 3-hydroxybenzoate, 4-hydroxybenzoate, and benzoate. ShyA shows activity on o-hydroxylated benzoic acids, such as 4-aminosalicylic acid, 2,3-dihydroxybenzoic acid, and gentisic acid, but not on benzoic acid derivatives that are not o-hydroxylated. The enzyme also exhibits NADH oxidase activity besides the more rapid hydroxylase activity
-
-
-
additional information
?
-
-
apoenzyme-flavin interaction
-
-
?
additional information
?
-
-
no activity with 2,1,3-benzothiadiazole and 2,6-dichloroisonicotinic acid
-
-
?
additional information
?
-
the ability of wild-type from strain 46422 and the FgshyC mutant to metabolize salicylate (SA) is tested. When SA is added to liquid cultures of either wild-type strain 46422 or the FgShyC mutant, it is degraded similarly. This demonstrates that Fusarium graminearum produces salicylate hydroxylases and argues against this role for FgShyC. In addition, recombinant FgShyC protein expressed in Escherichia coli does not convert SA to catechol in a colorimetric plate assay. Although FgShyC has sequence homology with salicylic hydroxylase genes, it does not function as a salicylate hydroxylase in our assays
-
-
-
additional information
?
-
the ability of wild-type from strain 46422 and the FgshyC mutant to metabolize salicylate (SA) is tested. When SA is added to liquid cultures of either wild-type strain 46422 or the FgShyC mutant, it is degraded similarly. This demonstrates that Fusarium graminearum produces salicylate hydroxylases and argues against this role for FgShyC. In addition, recombinant FgShyC protein expressed in Escherichia coli does not convert SA to catechol in a colorimetric plate assay. Although FgShyC has sequence homology with salicylic hydroxylase genes, it does not function as a salicylate hydroxylase in our assays
-
-
-
additional information
?
-
-
the ability of wild-type from strain 46422 and the FgshyC mutant to metabolize salicylate (SA) is tested. When SA is added to liquid cultures of either wild-type strain 46422 or the FgShyC mutant, it is degraded similarly. This demonstrates that Fusarium graminearum produces salicylate hydroxylases and argues against this role for FgShyC. In addition, recombinant FgShyC protein expressed in Escherichia coli does not convert SA to catechol in a colorimetric plate assay. Although FgShyC has sequence homology with salicylic hydroxylase genes, it does not function as a salicylate hydroxylase in our assays
-
-
-
additional information
?
-
the ability of wild-type from strain 46422 and the FgshyC mutant to metabolize salicylate (SA) is tested. When SA is added to liquid cultures of either wild-type strain 46422 or the FgShyC mutant, it is degraded similarly. This demonstrates that Fusarium graminearum produces salicylate hydroxylases and argues against this role for FgShyC. In addition, recombinant FgShyC protein expressed in Escherichia coli does not convert SA to catechol in a colorimetric plate assay. Although FgShyC has sequence homology with salicylic hydroxylase genes, it does not function as a salicylate hydroxylase in our assays
-
-
-
additional information
?
-
-
mechanism
-
-
?
additional information
?
-
-
mechanism
-
-
?
additional information
?
-
-
mechanism
-
-
?
additional information
?
-
-
mechanism
-
-
?
additional information
?
-
-
mechanism
-
-
?
additional information
?
-
-
enzyme catalyzes formation of catechol from substrate analogues such as o-nitro-, o-amino-, o-iodo-, o-bromo- and o-chlorophenol by removing the ortho substituted groups
-
-
?
additional information
?
-
-
enzyme catalyses hydroxylation and dehalogenation of o-halogenophenols and also denitrification of o-nitrophenol with unusual stoichiometry
-
-
?
additional information
?
-
-
by chemical treatment of the enzyme with dicarbonyl reagents, such as glyoxal, the original oxygenase activity is converted to the salicylate-dependent NADH-dehydrogenase activity with free FAD as electron acceptor
-
-
?
additional information
?
-
-
o-fluorophenol is not converted to catechol, though NADH oxidation is observed
-
-
?
additional information
?
-
product identification by NMR
-
-
-
additional information
?
-
salicylate hydroxylase NahG has a single redox site in which FAD is reduced by NADH, the O2 is activated by the reduced flavin, and salicylate undergoes an oxidative decarboxylation by a C(4a)-hydroperoxyflavin intermediate to give catechol
-
-
-
additional information
?
-
salicylate hydroxylase NahG has a single redox site in which FAD is reduced by NADH, the O2 is activated by the reduced flavin, and salicylate undergoes an oxidative decarboxylation by a C(4a)-hydroperoxyflavin intermediate to give catechol
-
-
-
additional information
?
-
product identification by NMR
-
-
-
additional information
?
-
-
product identification by NMR
-
-
-
additional information
?
-
-
mechanism
-
-
?
additional information
?
-
the recombinant SlSA1H enzyme shows high substrate specificity. Poor activity with 6-methylsalicylate, no activity with 3-hydroxybenzoate, 4-hydroxybenzoate, 2-methoxybenzoate, 2-coumarate, gallate, shikimate, 2,3-dihydroxybenzoate, 2,4-dihydroxybenzoate, 2,5-dihydroxybenzoate, 2,6-dihydroxybenzoate, 3,4-dihydroxybenzoate, 3,5-dihydroxybenzoate, 3-methylsalicylate, 4-methylsalicylate, and 5-methylsalicylate
-
-
-
additional information
?
-
-
the recombinant SlSA1H enzyme shows high substrate specificity. Poor activity with 6-methylsalicylate, no activity with 3-hydroxybenzoate, 4-hydroxybenzoate, 2-methoxybenzoate, 2-coumarate, gallate, shikimate, 2,3-dihydroxybenzoate, 2,4-dihydroxybenzoate, 2,5-dihydroxybenzoate, 2,6-dihydroxybenzoate, 3,4-dihydroxybenzoate, 3,5-dihydroxybenzoate, 3-methylsalicylate, 4-methylsalicylate, and 5-methylsalicylate
-
-
-
additional information
?
-
-
1-hydroxy-2-naphthoate, which is an intermediate in phenanthrene degradation, is not hydroxylated by PhnII, but it induces a high rate of uncoupled oxidation of NADH
-
-
?