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1.14.12.7: phthalate 4,5-dioxygenase

This is an abbreviated version!
For detailed information about phthalate 4,5-dioxygenase, go to the full flat file.

Word Map on EC 1.14.12.7

Reaction

Phthalate
+
NADH
 +
H+
 +
O2
=
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate
 +
NAD+

Synonyms

3,4-phthalate dioxygenase, oxygenase, phthalate 4,5-di-, PA 4,5-dioxygenase, PDO, phthalate 3,4-dioxygenase, phthalate dioxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.7 phthalate 4,5-dioxygenase

Reference

topprint

Reference on EC 1.14.12.7 - phthalate 4,5-dioxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Batie, C.J.; LaHaie, E.; Ballou, D.P.
Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia
J. Biol. Chem.
262
1510-1518
1987
Burkholderia cepacia
Manually annotated by BRENDA team
Dickinson, R.; Franks, N.P.; Lieb, W.R.
Thermodynamics of anesthetic /protein interactions
Biophys. J.
64
1264-1271
1993
Photinus pyralis
Manually annotated by BRENDA team
Batie, C.J.; Ballou, D.P.
Phthalate dioxygenase
Methods Enzymol.
188
61-70
1990
Burkholderia cepacia, Burkholderia cepacia DB01
Manually annotated by BRENDA team
Cline, J.F.; Hoffman, B.M.; Mims, W.B.; LaHaie, E.; Ballou, D.P.; Fee, J.A.
Evidence for N coordination to Fe in the [2Fe-2S] clusters of Thermus Rieske protein and phthalate dioxygenase from Pseudomonas
J. Biol. Chem.
260
3251-3254
1985
Burkholderia cepacia
Manually annotated by BRENDA team
Gurbiel, R.J.; Batie, C.J.; Sivaraja, M.; True, A.E.; Fee, J.A.; Hoffman, B.M.; Ballou, D.P.
Electron-nuclear double resonance spectroscopy of 15N-enriched phthalate dioxygenase from Pseudomonas cepacia proves that two histidines are coordinated to the [2Fe-2S] Rieske-type clusters
Biochemistry
28
4861-4871
1989
Burkholderia cepacia
Manually annotated by BRENDA team
Pavel, E.G.; Martins, L.J.; Ellis, W.R., Jr.; Solomon, E.I.
Magnetic circular dichroism studies of exogenous ligand and substrate binding to the non-heme ferrous active site in phthalate dioxygenase
Chem. Biol.
1
173-183
1994
Burkholderia cepacia
Manually annotated by BRENDA team
Gassner, G.T.; Ballou, D.P.; Landrum, G.A.; Whittaker, J.W.
Magnetic circular dichroism studies on the mononuclear ferrous active site of phthalate dioxygenase from Pseudomonas cepacia show a change of ligation state on substrate binding
Biochemistry
32
4820-4825
1993
Burkholderia cepacia
Manually annotated by BRENDA team
Tsang, H.T.; Batie, C.J.; Ballou, D.P.; Penner-Hahn, J.E.
X-ray absoprtion spectroscopie of the [2Fe-2S] Rieske cluster in Pseudomonas cepacia phthalate dioxygenase. Determination of core dimensions and iron ligation
Biochemistry
28
7233-7240
1989
Burkholderia cepacia
Manually annotated by BRENDA team
Tarasev, M.; Rhames, F.; Ballou, D.P.
Rates of the phthalate dioxygenase reaction with oxygen are dramatically increased by interactions with phthalate and phthalate oxygenase reductase
Biochemistry
43
12799-12808
2004
Burkholderia cepacia, Burkholderia cepacia DB01
Manually annotated by BRENDA team
Tarasev, M.; Ballou, D.P.
Chemistry of the catalytic conversion of phthalate into its cis-dihydrodiol during the reaction of oxygen with the reduced form of phthalate dioxygenase
Biochemistry
44
6197-6207
2005
Burkholderia cepacia, Burkholderia cepacia DB01
Manually annotated by BRENDA team
Tarasev, M.; Pinto, A.; Kim, D.; Elliott, S.J.; Ballou, D.P.
The bridging aspartate 178 in phthalate dioxygenase facilitates interactions between the Rieske center and the iron(II)--mononuclear center
Biochemistry
45
10208-10216
2006
Burkholderia cepacia, Burkholderia cepacia DB01
Manually annotated by BRENDA team
Pinto, A.; Tarasev, M.; Ballou, D.P.
Substitutions of the bridging aspartate 178 result in profound changes in the reactivity of the Rieske center of phthalate dioxygenase
Biochemistry
45
9032-9041
2006
Burkholderia cepacia, Burkholderia cepacia DB01
Manually annotated by BRENDA team
Jaganaman, S.; Pinto, A.; Tarasev, M.; Ballou, D.P.
High levels of expression of the iron-sulfur proteins phthalate dioxygenase and phthalate dioxygenase reductase in Escherichia coli
Protein Expr. Purif.
52
273-279
2007
Burkholderia cepacia
Manually annotated by BRENDA team
Tarasev, M.; Kaddis, C.S.; Yin, S.; Loo, J.A.; Burgner, J.; Ballou, D.P.
Similar enzymes, different structures: phthalate dioxygenase is an alpha3alpha3 stacked hexamer, not an alpha3beta3 trimer like "normal" Rieske oxygenases
Arch. Biochem. Biophys.
466
31-39
2007
Burkholderia cepacia
Manually annotated by BRENDA team
Tarasev, M.; Pullela, S.; Ballou, D.P.
Distal end of 105-125 loop - a putative reductase binding domain of phthalate dioxygenase
Arch. Biochem. Biophys.
487
10-18
2009
Burkholderia cepacia, Burkholderia cepacia DB01
Manually annotated by BRENDA team
Jin, D.C.; Liang, R.X.; Dai, Q.Y.; Zhang, R.Y.; Wu, X.L.; Chao, W.L.
Biodegradation of di-n-butyl phthalate by Rhodococcus sp. JDC-11 and molecular detection of 3, 4-phthalate dioxygenase gene
J. Microbiol. Biotechnol.
20
1440-1445
2010
Rhodococcus sp. (B8YFX2), Rhodococcus sp. JDC-11 (B8YFX2)
Manually annotated by BRENDA team
Benjamin, S.; Kamimura, N.; Takahashi, K.; Masai, E.
Achromobacter denitrificans SP1 efficiently utilizes 16 phthalate diesters and their downstream products through protocatechuate 3,4-cleavage pathway
Ecotoxicol. Environ. Saf.
134P1
172-178
2016
Achromobacter denitrificans, Achromobacter denitrificans SP1
Manually annotated by BRENDA team