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1.14.12.23: nitroarene dioxygenase

This is an abbreviated version!
For detailed information about nitroarene dioxygenase, go to the full flat file.

Word Map on EC 1.14.12.23

Reaction

nitrobenzene
+
NADH
+
O2
=
catechol
+
nitrite
+
NAD+

Synonyms

2-chloronitrobenzene dioxygenase, 2NTDO, cnbA, cnbAa, cnbAb, cnbAc, cnbAd, MntAa, MntAb, MntAc, MntAd, naphthalene dioxygenase, nbzAa, nbzAb, nbzAc, nbzAd

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.23 nitroarene dioxygenase

Systematic Name

Systematic Name on EC 1.14.12.23 - nitroarene dioxygenase

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SYSTEMATIC NAME
IUBMB Comments
nitrobenzene,NADH:oxygen oxidoreductase (1,2-hydroxylating, denitrifying)
This enzyme is a member of the naphthalene family of bacterial Rieske non-heme iron dioxygenases. It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase), and an alpha3beta3 oxygenase. The enzyme forms of a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite. It can typically act on many different nitroaromatic compounds, including chlorinated species. Enzymes found in different strains may have different substrate preferences. Requires Fe2+.