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1.14.11.9: flavanone 3-dioxygenase

This is an abbreviated version!
For detailed information about flavanone 3-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.9

Reaction

a (2S)-flavan-4-one
+
2-oxoglutarate
+
O2
=
a (2R,3R)-dihydroflavonol
+
succinate
+
CO2

Synonyms

(2S)-flavanone 3-hydroxylase, AaF3H, AcF3H, BnF3H, CsF3H, CtF3H, F3H, F3H protein, F3H1, F3H2, FHT, FHTPH, flavanone 3-dioxygenase, flavanone 3-hydroxylase, flavanone 3beta-hydroxylase, flavanone synthase I, flavanone-3-hydroxylase, FLS1, FLS2, FS I, LcF3H, naringenin 3-dioxygenase, naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating), oxygenase, flavanone 3-di-, PeF3H, PgF3H, PnF3H, RtF3H1, RtF3H2, VcF3H

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.9 flavanone 3-dioxygenase

Expression

Expression on EC 1.14.11.9 - flavanone 3-dioxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
decrease at stage of flowering
downregulation of flavanone 4-reductase leads to upregulation of other flavanoid pathway genes, inclunding the flavanone 3-hydroxylase, feedback regulation of flavonoid gene expression, overview
-
expression is down-regulated in response to drought, abscisic acid and gibberellic acid treatment
expression is up-regulated in response to wounding
flavanone 3-hydroxylase expression increases in response to N depletion, in agreement with a corresponding increase in flavonoid and caffeoyl content in tomato leaves, and/or to lower temperatures, overview. The effects of N depletion are apparently mediated through the overall regulators of the pathway the MYB transcription factor ANT1, ANTHOCYANIN 1, and SlJAF13, a bHLH transcription factor orthologue of petunia JAF13 and maize RED genes
highly expressed after Endoconidiophora polonica infection
increase in transcript level of PgF3H with respect to the growth of the fruits
no induction of the SbF3H1 and SbF3H2 genes by methyljasmonate
PnF3H expression levels increase by 2.49fold at 1 h and then slightly decrease to 1.47fold at 24 h with cold treatment. For the simulated drought stress (i.e. 20% PEG 6000), the PnF3H expression levels enhance by 2.39fold at 3 h and the transcript abundance remains high up to 12 h. In the UV-B radiation, the PnF3H expression levels increase and reach the maximum level of 4.57fold at 3 h. After exogenous abscisic acid treatment, the PnF3H expression levels increase quickly and reach the maximum level of 2.57fold at 0.5 h
-
positive correlation between absisic acid and LcF3H expression level
rapid increase in gene expression of RsF3H under stress, both UV-B radiation and drought stress induce an increase in RsF3H enzyme activity and the accumulation of the products in the flavonoid biosynthetic pathway (total flavonoid and anthocyanin), overview
the enzyme flavanone 3-hydroxylase is induced by methyl jasmonate. Further metabolite analysis shows the increasing tendency of quinochalcones and flavonols, such as hydroxysafflor yellow A, kaempferol-3-O-beta-D-glucoside, kaempferol-3-O-beta-rutinoside, rutin, carthamin, and luteolin, in the quinochalcone-type safflower line. Also, the accumulation of kaempferol-3-O-beta-rutinoside and kaempferol-3-O-beta-D-glucoside in flavonols-typed safflower line shows enhanced accumulation pattern after methyl jasmonate treatment. Other flavonols, such as kaempferol, dihydrokaempferol and quercetin-3-O-beta-D-glucoside, in flavonols-typed safflower line present downregulation in respons to the methyl jasmonate stimulus
the enzyme is significantly up-regulated in the roots of hydroponic Boehmeria nivea, and higher total flavonoids content in the hydroponic ramie roots is also observed
the transcript levels of LcF3H shows significant decrease when plants are treated by exogenous nordihydroguaiaretic acid (100 mM) application together with drought stress treatment comparing to that treated with drought stress alone, the decrease in LcF3H expression under drought stress is less in overexpressing lines compared to the control plants
transcript levels of the two F3H genes, RtF3H1 and RtF3H2, are increased in Reaumuria trigyna not only under salt stress but also under drought and cold stresses, and by abscisic acid