Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.11.7: procollagen-proline 3-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-proline 3-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.7

Reaction

[procollagen]-L-proline
+
2-oxoglutarate
 +
O2
=
[procollagen]-trans-3-hydroxy-L-proline
 +
succinate
 +
CO2

Synonyms

LEPRE1, Leprel1, Leprel2, More, oxygenase, protocollagen proline 3-di-, P3H1, P3H2, P3H3, PHD3, proline,2-oxoglutarate 3-dioxygenase, prolyl 3-hydroxylase, prolyl 3-hydroxylase 1, prolyl 3-hydroxylase 2, prolyl 3-hydroxylase-2, prolyl hydroxylase, prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating, protocollagen proline 3-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.7 procollagen-proline 3-dioxygenase

Reference

topprint

Reference on EC 1.14.11.7 - procollagen-proline 3-dioxygenase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Majamaa, K.; Turpeenniemi-Hujanen, T.M.; Latipää, P.; Gunzler, V.; Hanauske-Abel, H.M.; Hassinen, I.E.; Kivirikko, K.I.
Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate
Biochem. J.
229
127-133
1985
Gallus gallus
Manually annotated by BRENDA team
Tryggvason, K.; Majamaa, K.; Risteli, J.; Kivirikko, K.I.
Partial purification and characterization of chick-embryo prolyl 3-hydroxylase
Biochem. J.
183
303-307
1979
Gallus gallus
Manually annotated by BRENDA team
Risteli, J.; Tryggvason, K.; Kivirikko, K.I.
A rapid assay for prolyl 3-hydroxylase activity
Anal. Biochem.
84
423-431
1978
Rattus norvegicus
Manually annotated by BRENDA team
Risteli, J.; Tryggvason, K.; Kivirikko, K.I.
Prolyl 3-hydroxylase: partial characterization of the enzyme from rat kidney cortex
Eur. J. Biochem.
73
485-492
1977
Rattus norvegicus
Manually annotated by BRENDA team
Petersen, L.; Olewinski, R.; Salmon, P.; Connors, N.
Novel proline hydroxylase activities in the pneumocandin-producing fungus Glarea lozoyensis responsible for the formation of trans 3- and trans 4-hydroxyproline
Appl. Microbiol. Biotechnol.
62
263-267
2003
Glarea lozoyensis
Manually annotated by BRENDA team
Morello, R.; Bertin, T.K.; Chen, Y.; Hicks, J.; Tonachini, L.; Monticone, M.; Castagnola, P.; Rauch, F.; Glorieux, F.H.; Vranka, J.; Baechinger, H.P.; Pace, J.M.; Schwarze, U.; Byers, P.H.; Weis, M.; Fernandes, R.J.; Eyre, D.R.; Yao, Z.; Boyce, B.F.; Lee, B.
CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta
Cell
127
291-304
2006
Mus musculus
Manually annotated by BRENDA team
Tiainen, P.; Pasanen, A.; Sormunen, R.; Myllyharju, J.
Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IV
J. Biol. Chem.
283
19432-19439
2008
Homo sapiens (Q32P28), Homo sapiens (Q8IVL5), Homo sapiens
Manually annotated by BRENDA team
Shah, R.; Smith, P.; Purdie, C.; Quinlan, P.; Baker, L.; Aman, P.; Thompson, A.M.; Crook, T.
The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer
Br. J. Cancer
100
1687-1696
2009
Homo sapiens (Q8IVL5), Homo sapiens (Q8IVL6)
Manually annotated by BRENDA team
Vranka, J.; Stadler, H.S.; Baechinger, H.P.
Expression of prolyl 3-hydroxylase genes in embryonic and adult mouse tissues
Cell Struct. Funct.
34
97-104
2009
Mus musculus (Q3V1T4), Mus musculus (Q8CG70), Mus musculus (Q8CG71), Mus musculus
Manually annotated by BRENDA team
Marini, J.C.; Cabral, W.A.; Barnes, A.M.
Null mutations in LEPRE1 and CRTAP cause severe recessive osteogenesis imperfecta
Cell Tissue Res.
339
59-70
2009
Homo sapiens
Manually annotated by BRENDA team
Chang, W.; Barnes, A.M.; Cabral, W.A.; Bodurtha, J.N.; Marini, J.C.
Prolyl 3-hydroxylase 1 and CRTAP are mutually stabilizing in the endoplasmic reticulum collagen prolyl 3-hydroxylation complex
Hum. Mol. Genet.
19
223-234
2009
Homo sapiens (Q32P28), Homo sapiens
Manually annotated by BRENDA team
Ishikawa, Y.; Wirz, J.; Vranka, J.A.; Nagata, K.; Baechinger, H.P.
Biochemical characterization of the prolyl 3-hydroxylase 1 cartilage-associated protein cyclophilin B complex
J. Biol. Chem.
284
17641-17647
2009
Gallus gallus (Q6JHU8)
Manually annotated by BRENDA team
Liu, Y.; Huo, Z.; Yan, B.; Lin, X.; Zhou, Z.N.; Liang, X.; Zhu, W.; Liang, D.; Li, L.; Liu, Y.; Zhao, H.; Sun, Y.; Chen, Y.H.
Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells
Biochem. Biophys. Res. Commun.
401
231-237
2010
Rattus norvegicus
Manually annotated by BRENDA team
Vranka, J.A.; Pokidysheva, E.; Hayashi, L.; Zientek, K.; Mizuno, K.; Ishikawa, Y.; Maddox, K.; Tufa, S.; Keene, D.R.; Klein, R.; Baechinger, H.P.
Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones
J. Biol. Chem.
285
17253-17262
2010
Mus musculus
Manually annotated by BRENDA team
Fernandes, R.J.; Farnand, A.W.; Traeger, G.R.; Weis, M.A.; Eyre, D.R.
A role for prolyl 3-hydroxylase 2 in post-translational modification of fibril-forming collagens
J. Biol. Chem.
286
30662-30669
2011
Rattus norvegicus
Manually annotated by BRENDA team
Fujita, N.; Gogate, S.S.; Chiba, K.; Toyama, Y.; Shapiro, I.M.; Risbud, M.V.
Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-alpha (TNF-alpha) on cells of the nucleus pulposus through co-activation of nuclear factor kappaB (NF-kappaB)/p65 signaling
J. Biol. Chem.
287
39942-39953
2012
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Pokidysheva, E.; Zientek, K.D.; Ishikawa, Y.; Mizuno, K.; Vranka, J.A.; Montgomery, N.T.; Keene, D.R.; Kawaguchi, T.; Okuyama, K.; Baechinger, H.P.
Posttranslational modifications in type I collagen from different tissues extracted from wild type and prolyl 3-hydroxylase 1 null mice
J. Biol. Chem.
288
24742-24752
2013
Mus musculus
Manually annotated by BRENDA team
Chen, R.L.; Nagel, S.; Papadakis, M.; Bishop, T.; Pollard, P.; Ratcliffe, P.J.; Pugh, C.W.; Buchan, A.M.
Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice
J. Physiol.
590
4079-4091
2012
Mus musculus
Manually annotated by BRENDA team
Hudson, D.M.; Joeng, K.S.; Werther, R.; Rajagopal, A.; Weis, M.; Lee, B.H.; Eyre, D.R.
Post-translationally abnormal collagens of prolyl 3-hydroxylase-2 null mice offer a pathobiological mechanism for the high myopia linked to human LEPREL1 mutations
J. Biol. Chem.
290
8613-8622
2015
Mus musculus (Q8CG71), Mus musculus
Manually annotated by BRENDA team
Homan, E.P.; Lietman, C.; Grafe, I.; Lennington, J.; Morello, R.; Napierala, D.; Jiang, M.M.; Munivez, E.M.; Dawson, B.; Bertin, T.K.; Chen, Y.; Lua, R.; Lichtarge, O.; Hicks, J.; Weis, M.A.; Eyre, D.; Lee, B.H.
Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues
PLoS Genet.
10
e1004121
2014
Mus musculus (Q3V1T4), Mus musculus
Manually annotated by BRENDA team
Pokidysheva, E.; Boudko, S.; Vranka, J.; Zientek, K.; Maddox, K.; Moser, M.; Faessler, R.; Ware, J.; Baechinger, H.
Biological role of prolyl 3-hydroxylation in type IV collagen
Proc. Natl. Acad. Sci. USA
111
161-166
2014
Mus musculus (Q8CG71)
Manually annotated by BRENDA team
Pignata, P.; Apicella, I.; Cicatiello, V.; Puglisi, C.; Magliacane Trotta, S.; Sanges, R.; Tarallo, V.; De Falco, S.
Prolyl 3-hydroxylase 2 is a molecular player of angiogenesis
Int. J. Mol. Sci.
22
3896
2021
Mus musculus (Q8CG71), Homo sapiens (Q8IVL5), Homo sapiens
Manually annotated by BRENDA team