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1.14.11.7: procollagen-proline 3-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-proline 3-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.7

Reaction

[procollagen]-L-proline
+
2-oxoglutarate
 +
O2
=
[procollagen]-trans-3-hydroxy-L-proline
 +
succinate
 +
CO2

Synonyms

LEPRE1, Leprel1, Leprel2, More, oxygenase, protocollagen proline 3-di-, P3H1, P3H2, P3H3, PHD3, proline,2-oxoglutarate 3-dioxygenase, prolyl 3-hydroxylase, prolyl 3-hydroxylase 1, prolyl 3-hydroxylase 2, prolyl 3-hydroxylase-2, prolyl hydroxylase, prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating, protocollagen proline 3-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.7 procollagen-proline 3-dioxygenase

KM Value

KM Value on EC 1.14.11.7 - procollagen-proline 3-dioxygenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.07
(Gly-L-Pro-L-4-hydroxyproline)5
isoform P3H2, pH 7.8, 37°C
0.003 - 0.08
2-oxoglutarate
0.26
L-Leu-L-Asn-Gly-L-Leu-L-4Hyp-Gly-L-Pro-L-Ile-Gly-L-Pro-L-4Hyp-Gly-L-Pro-L-Arg-Gly-L-Arg-L-Thr-Gly-L-Asp-L-Ala-Gly
isoform P3H2, pH 7.8, 37°C
0.07
L-Pro-L-Thr-Gly-L-Pro-L-Arg-Gly-L-Phe-L-Pro-Gly-L-Pro-L-4-hydroxyproline-Gly-L-Pro-L-Asp-Gly-L-Leu-L-4-hydroxyproline-Gly-L-Ser-L-Met-Gly
isoform P3H2, pH 7.8, 37°C
0.26
L-Ser-L-Lys-Gly-L-Glu-L-Gln-Gly-L-Phe-L-Met-Gly-L-Pro-L-4-hydroxyproline-Gly-L-Pro-L-Gln-Gly-L-Gln-L-4-hydroyproline-Gly-L-Leu-L-4-hydroxyproline-Gly
isoform P3H2, pH 7.8, 37°C
0.03
O2
-
-
0.000034
Procollagen
-
-
-