1.14.11.51: DNA N6-methyladenine demethylase
This is an abbreviated version!
For detailed information about DNA N6-methyladenine demethylase, go to the full flat file.
Word Map on EC 1.14.11.51
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1.14.11.51
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dioxygenase
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demethylation
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histone
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2-oxoglutarate-dependent
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abasic
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alkbh7
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eraser
- 1.14.11.51
- dioxygenase
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demethylation
- histone
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2-oxoglutarate-dependent
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abasic
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alkbh7
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eraser
Reaction
Synonyms
6mA DNA demethylase, ALKBH1, DMAD, DNA 6mA demethylase, NMAD, NMAD-1
ECTree
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Engineering
Engineering on EC 1.14.11.51 - DNA N6-methyladenine demethylase
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C118A
m6A demethylase activity similar to wild-type, about 25% decrease in apurinic/apyrimidinic lyase activity
C118A/C129A
about 50% decrease in m6A demethylase activity, about 20% decrease in apurinic/apyrimidinic lyase activity
C129A
about 90% decrease in m6A demethylase activity, about 30% decrease in apurinic/apyrimidinic lyase activity
D233A
H113A/C118A/C129A/H134A
no residual m6A demethylase activity, about 55% decrease in apurinic/apyrimidinic lyase activity
H231A
H287A
K133A
about 50% decrease in m6A demethylase activity, about 45% decrease in apurinic/apyrimidinic lyase activity
R338A
residue plays an important role in substrate recognition and catalysis
R344A
mutation in highly conserved residue, strong decrease in demethylation ability
Y184A
mutation in highly conserved residue, strong decrease in demethylation ability
K158A
mutation of basic residue of Flip1 region, abolishes N6-mA demethylation activity of ALKBH1
R159A
mutation of basic residue of Flip1 region, abolishes N6-mA demethylation activity of ALKBH1
R160A
mutation of basic residue of Flip1 region, abolishes N6-mA demethylation activity of ALKBH1
R167A
mutation of basic residue of Flip1 region, abolishes N6-mA demethylation activity of ALKBH1
R169A
mutation of basic residue of Flip1 region, abolishes N6-mA demethylation activity of ALKBH1
no residual m6A demethylase activity, about 30% decrease in apurinic/apyrimidinic lyase activity
D233A
residue plays an important role in substrate recognition and catalysis
no residual m6A demethylase activity, about 20% decrease in apurinic/apyrimidinic lyase activity
H231A
residue plays an important role in substrate recognition and catalysis
no residual m6A demethylase activity, about 25% decrease in apurinic/apyrimidinic lyase activity
H287A
residue plays an important role in substrate recognition and catalysis