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1.14.11.48: xanthine dioxygenase

This is an abbreviated version!
For detailed information about xanthine dioxygenase, go to the full flat file.

Reaction

xanthine
+
2-oxoglutarate
+
O2
=
Urate
+
succinate
+
CO2

Synonyms

alpha-ketoglutarate-dependent xanthine hydroxylase, AO090001000152, TauD domain-containing protein, XanA, xanthine/alpha-ketoglutarate dioxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.48 xanthine dioxygenase

pH Optimum

pH Optimum on EC 1.14.11.48 - xanthine dioxygenase

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
-
enzyme isolated from Aspergillus nidulans
7 - 8
-
the recombinant enzyme isolated from Escherichia coli exhibits a narrow pH optimum of 7.0-8.0 with pH 7.4 yielding optimal activity for Tris, MOPS, MES, imidazole, and HEPES buffers