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1.14.11.31: thebaine 6-O-demethylase

This is an abbreviated version!
For detailed information about thebaine 6-O-demethylase, go to the full flat file.

Word Map on EC 1.14.11.31

Reaction

thebaine
+
2-oxoglutarate
+
O2
=
neopinone
+
formaldehyde
+
succinate
+
CO2

Synonyms

Diox1, T6ODM

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.31 thebaine 6-O-demethylase

Substrates Products

Substrates Products on EC 1.14.11.31 - thebaine 6-O-demethylase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R,S)-canadine + 2-oxoglutarate + O2
?
show the reaction diagram
-
a protoberberine, 32% of activity with oripavine
-
-
?
(R,S)-tetrahydropalmatine + 2-oxoglutarate + O2
?
show the reaction diagram
-
a protoberberine, O-demethylation, below 1% of activity with oripavine
-
-
?
(R,S)-tetrahydropapaverine + 2-oxoglutarate + O2
?
show the reaction diagram
-
a 1-benzylisoquinoline, O-demethylation, 2.1% of activity with oripavine
-
-
?
allocryptopine + 2-oxoglutarate + O2
?
show the reaction diagram
-
a protopine, O-demethylation, 9.5% of activity with oripavine
-
-
?
cryptopine + 2-oxoglutarate + O2
?
show the reaction diagram
-
a protopine, O-demethylation, below 1% of activity with oripavine
-
-
?
oripavine + 2-oxoglutarate + O2
?
show the reaction diagram
-
a morphinan, best substrate
-
-
?
oripavine + 2-oxoglutarate + O2
morphinane + formaldehyde + succinate + CO2
show the reaction diagram
-
-
-
-
?
oripavine + 2-oxoglutarate + O2
morphinone + formaldehyde + succinate + CO2
show the reaction diagram
papaverine + 2-oxoglutarate + O2
?
show the reaction diagram
-
a 1-benzylisoquinoline,O-demethylation, below 1% of activity with oripavine
-
-
?
thebaine + 2-oxoglutarate + O2
codeinone + formaldehyde + succinate + CO2
show the reaction diagram
-
-
-
-
?
thebaine + 2-oxoglutarate + O2
neopinone + formaldehyde + succinate + CO2
show the reaction diagram
additional information
?
-