1.14.11.31: thebaine 6-O-demethylase

This is an abbreviated version!
For detailed information about thebaine 6-O-demethylase, go to the full flat file.

Word Map on EC 1.14.11.31

1.14.11.31

poppy

opium

somniferum

codeine

papaver

benzylisoquinoline

o-demethylation

dioxygenases

acinetobacter

capsule

virus-induced

morphinan

endophyte

reticuline

non-heme

Reaction

Synonyms

Diox1, T6ODM

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.31 thebaine 6-O-demethylase

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Results	in table
27	AA Sequence
2	Cloned(Commentary)
1	Crystallization (Commentary)
2	Expression
6	General Information
1	Inhibitors
3	kcat/KM [mM/s]
1	Ki Value [mM]
3	KM Value [mM]
2	Metals/Ions
7	Natural Substrates/ Products (Substrates)
7	Organism
6	Pathway
2	PDB ID
2	pH Optimum
1	Purification (Commentary)
2	Reaction
7	Reference
1	Source Tissue
19	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Turnover Number [1/s]

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Reference on EC 1.14.11.31 - thebaine 6-O-demethylase

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700357

Hagel, J.M.; Facchini, P.J.

Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy.

Nat. Chem. Biol.

273-275

2010

Papaver somniferum

20228795

725537

Farrow, S.C.; Facchini, P.J.

Dioxygenases catalyze O-demethylation and O,O-demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy

J. Biol. Chem.

288

28997-29012

2013

Papaver somniferum

23928311

743439

Hashemi, S.; Naghavi, M.

Production and gene expression of morphinan alkaloids in hairy root culture of Papaver orientale L. using abiotic elicitors

Plant Cell

125

31-41

2016

Papaver orientale

743555

Pandey, S.S.; Singh, S.; Babu, C.S.; Shanker, K.; Srivastava, N.K.; Kalra, A.

Endophytes of opium poppy differentially modulate host plant productivity and genes for the biosynthetic pathway of benzylisoquinoline alkaloids

Planta

243

1097-1114

2016

Papaver somniferum

26794966

764840

Singh, W.; Hui, C.; Li, C.; Huang, M.

Thebaine is selectively demethylated by thebaine 6-O-demethylase and codeine-3-O-demethylase at distinct binding sites A computational study

Inorg. Chem.

10199-10214

2021

Papaver somniferum (D4N500)

34213893

764879

Kachhap, S.; Wojdyla, Z.; Komorek, P.; Kluza, A.; Kurpiewska, K.; Jachimska, B.; Borowski, T.

It takes two to tango - The case of thebaine 6-O-demethylase

Int. J. Biol. Macromol.

163

718-729

2020

Papaver somniferum (D4N500)

32650010

765284

Kluza, A.; Niedzialkowska, E.; Kurpiewska, K.; Wojdyla, Z.; Quesne, M.; Kot, E.; Porebski, P.J.; Borowski, T.

Crystal structure of thebaine 6-O-demethylase from the morphine biosynthesis pathway

J. Struct. Biol.

202

229-235

2018

Papaver somniferum (D4N500), Papaver somniferum

29408320