1.14.11.30: hypoxia-inducible factor-asparagine dioxygenase

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For detailed information about hypoxia-inducible factor-asparagine dioxygenase, go to the full flat file.

Reaction

Synonyms

asparaginyl hydroxylase, asparaginyl-hydroxylase, factor inhibiting HIF, factor inhibiting HIF-1, factor inhibiting hypoxia inducible factor-1alpha, factor-inhibiting HIF, factor-inhibiting hypoxia inducible factor, factor-inhibiting hypoxia-inducible factor, FIH, FIH hydroxylase, HIF asparagine hydroxylase, HIF asparaginyl hydroxylase, HIF hydroxylase, HIF1AN, hypoxia-inducible factor 1-alpha inhibitor, hypoxia-inducible factor asparagine hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.30 hypoxia-inducible factor-asparagine dioxygenase

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Results	in table
5	Activating Compound
11	AA Sequence
3	Application
5	Cloned(Commentary)
2	Crystallization (Commentary)
57	Disease/ Diagnostics
1	Expression
19	General Information
13	IC50 Value
29	Inhibitors
6	kcat/KM [mM/s]
8	Ki Value [mM]
15	KM Value [mM]
9	Metals/Ions
15	Natural Substrates/ Products (Substrates)
18	Organism
29	PDB ID
4	pH Optimum
5	Protein Variants
5	Purification (Commentary)
1	Reaction
18	Reference
16	Source Tissue
37	Substrates and Products (Substrate)
1	Subunits
39	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
7	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.14.11.30 - hypoxia-inducible factor-asparagine dioxygenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2

hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2

7 entries

TRPV3 channel ankyrin repeat domain + 2-oxoglutarate + O2

?

Homo sapiens

-

-

742307

-

-

?

hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2

hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2

Homo sapiens

-

-

701220, 724225, 724523, 724847, 726079, 742307, 742895, 743379

-

-

?

hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2

hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2

Homo sapiens

-

activity of the hypoxia-inducible factor (HIF) complex is controlled by oxygen-dependent hydroxylation of prolyl and asparaginyl residues. Hydroxylation of specific prolyl residues by 2-oxoglutarate-dependent oxygenases mediates ubiquitinylation and proteasomal destruction of HIF-alpha. Hydroxylation of an asparagine residue (ASn803) in the C-terminal transactivation domain of HIF-alpha abrogates interaction with p300, preventing transcriptional activation

698722

-

-

?

hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2

hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2

Homo sapiens

-

the activity of hypoxia-inducible transcription factor HIF, an alphabeta heterodimer that has an essential role in adaptation to low oxygen availability, is regulated by two oxygen-dependent hydroxylation events. Hydroxylation of specific proline residues by HIF prolyl 4-hydroxylases targets the HIF-alpha subunit for proteasomal destruction, whereas hydroxylation of an asparagine in the C-terminal transactivation domain prevents its interaction with the transcriptional coactivator p300

659445

-

-

?

hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2

hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2

Homo sapiens

-

FIH hydroxylates Asn803 of HIF-1alpha

725647

-

-

?

hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2

hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2

Homo sapiens

-

FIH hydroxylates at the asparaginyl residue in the FIH transcriptional activation domain C-TAD

724696

-

-

?

hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2

hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2

Homo sapiens

-

HIF-1alpha

725596

-

-

?

hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2

hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2

Homo sapiens

Q9NWT6

hydroxylation at Asn803

743041

-

-

?