1.14.11.29: hypoxia-inducible factor-proline dioxygenase

This is an abbreviated version!
For detailed information about hypoxia-inducible factor-proline dioxygenase, go to the full flat file.

Reaction

Synonyms

Egl nine homolog 1, EGLN, EGLN1, Egln2, EGLN3, factor inhibiting HIF, FIH, HIF hydroxylase, HIF prolyl, HIF prolyl 4-hydroxylase, HIF prolyl hydroxylase, HIF-1alpha PHD3, HIF-1alpha prolyl hydroxylase 3, HIF-alpha prolyl-hydroxylase, HIF-P4H-1, HIF-P4H-2, HIF-P4H-3, HIF-PH, Hif-prolyl hydroxylase, HIF-prolyl hydroxylase domain 2, HIF-prolyl hydroxylase-2, HPH-1, HPH-2, HPH-3, hydroxylase domain enzyme, hypoxia-inducible factor prolyl hydroxylase 2, hypoxia-inducible factor prolyl hydroxylase domain 2, P4H-TM, PHD, PHD1, PHD2, PHD3, proline hydroxylase domain 2, prolyl 4-hydroxylase, prolyl hydroxylase, prolyl hydroxylase domain, prolyl hydroxylase domain protein, prolyl hydroxylase domain protein 2, prolyl hydroxylase-2, prolyl-4-hydroxylase 2, prolyl-4-hydroxylase domain 2, transmembrane prolyl 4-hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.29 hypoxia-inducible factor-proline dioxygenase

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Results	in table
10	Activating Compound
35	AA Sequence
6	Application
19	Cloned(Commentary)
5	Crystallization (Commentary)
803	Disease/ Diagnostics
4	Expression
43	General Information
66	IC50 Value
143	Inhibitors
13	kcat/KM [mM/s]
23	Ki Value [mM]
61	KM Value [mM]
1	Localization
14	Metals/Ions
3	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
62	Organism
59	PDB ID
5	pH Optimum
11	Protein Variants
11	Purification (Commentary)
1	Reaction
52	Reference
68	Source Tissue
99	Substrates and Products (Substrate)
5	Subunits
131	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
16	Turnover Number [1/s]

KM Value

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KM Value on EC 1.14.11.29 - hypoxia-inducible factor-proline dioxygenase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0007 - 0.06

2-oxoglutarate

6 entries

0.006 - 0.015

DALDLEMLAPYISMDDDFQL

3 entries

0.0366 - 0.1071

DALTLLAPAAGDTIISLDF

2 entries

-

0.13 - 0.38

DALTLLAPAAGDTIISLFG

2 entries

0.0008 - 0.0041

DLDLEALAPYIPADDDFQL

3 entries

0.01 - 0.02

DLDLEMLAPAIPMDDDFQL

2 entries

0.02

DLDLEMLAPGIPMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.03 - 0.1

DLDLEMLAPYIPMD

2 entries

0.009 - 0.1

DLDLEMLAPYIPMDD

3 entries

0.007 - 0.07

DLDLEMLAPYIPMDDDF

3 entries

0.0052 - 0.008

DLDLEMLAPYIPMDDDFQL

3 entries

0.006 - 0.008

DLDLEMLAPYIPMDDDFQLRSFDQ

2 entries

0.1306

DLDLEMLAPYIPTIISLDF

Homo sapiens

Q9GZT9

pH 7.5, 37°C

764482

-

0.007 - 0.014

DLEMLAPYIPMDDDFQL

2 entries

0.07 - 0.1

EEPDLSCLAPFVDTYDMMQM

2 entries

0.011 - 0.03

ELDLETLAPYIPMDGEDFQ

2 entries

0.05

EMLAPYIPMDD

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.007 - 0.08

EMLAPYIPMDDDFQL

3 entries

0.06 - 0.1

EPEELAQLAPTPGDAIISLD

2 entries

0.001 - 0.067

hypoxia-inducible factor-L-proline

5 entries

0.000016 - 0.00094

hypoxia-inducible factor1alpha C-terminal oxygen-dependent degradation domain-L-proline

2 entries

-

0.0047 - 0.023

hypoxia-inducible factor2alpha C-terminal oxygen-dependent degradation domain-L-proline

Homo sapiens

Q96KS0, Q9GZT9, Q9H6Z9

pH 7.5, 25°C, PHD3

724225

-

0.015

LAPYIPMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.1 - 0.76

O2

5 entries

additional information

additional information

4 entries

-

0.0007

2-oxoglutarate

Homo sapiens

Q9GZT9

mutant enzyme T387N, at pH 7.0 and 37°C

741910

0.0009

2-oxoglutarate

Homo sapiens

Q9GZT9

wild type isoform PHD2, at pH 7.0 and 37°C

741910

0.007

2-oxoglutarate

Homo sapiens

-

pH 7.0, 37°C

725647

0.012

2-oxoglutarate

Homo sapiens

Q9GZT9

mutant enzyme T387A, at pH 7.0 and 37°C

741910

0.055

2-oxoglutarate

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.06

2-oxoglutarate

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.006

DALDLEMLAPYISMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.007

DALDLEMLAPYISMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.015

DALDLEMLAPYISMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.0366

DALTLLAPAAGDTIISLDF

Homo sapiens

Q9GZT9

pH 7.5, 37°C

764482

-

0.1071

DALTLLAPAAGDTIISLDF

Homo sapiens

Q9GZT9

pH 7.5, 37°C

764482

-

0.13

DALTLLAPAAGDTIISLFG

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.38

DALTLLAPAAGDTIISLFG

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.0008

DLDLEALAPYIPADDDFQL

Homo sapiens

Q9GZT9

wild type isoform PHD2, at pH 7.0 and 37°C

741910

0.0014

DLDLEALAPYIPADDDFQL

Homo sapiens

Q9GZT9

mutant enzyme T387N, at pH 7.0 and 37°C

741910

0.0041

DLDLEALAPYIPADDDFQL

Homo sapiens

Q9GZT9

mutant enzyme T387A, at pH 7.0 and 37°C

741910

0.01

DLDLEMLAPAIPMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.02

DLDLEMLAPAIPMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.03

DLDLEMLAPYIPMD

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.1

DLDLEMLAPYIPMD

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.009

DLDLEMLAPYIPMDD

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.06

DLDLEMLAPYIPMDD

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.1

DLDLEMLAPYIPMDD

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.007

DLDLEMLAPYIPMDDDF

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.05

DLDLEMLAPYIPMDDDF

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.07

DLDLEMLAPYIPMDDDF

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.0052

DLDLEMLAPYIPMDDDFQL

Homo sapiens

Q9GZT9

pH 7.5, 37°C

764482

0.007

DLDLEMLAPYIPMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.008

DLDLEMLAPYIPMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.006

DLDLEMLAPYIPMDDDFQLRSFDQ

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.008

DLDLEMLAPYIPMDDDFQLRSFDQ

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.007

DLEMLAPYIPMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.014

DLEMLAPYIPMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.07

EEPDLSCLAPFVDTYDMMQM

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.1

EEPDLSCLAPFVDTYDMMQM

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.011

ELDLETLAPYIPMDGEDFQ

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.03

ELDLETLAPYIPMDGEDFQ

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.007

EMLAPYIPMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.035

EMLAPYIPMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.08

EMLAPYIPMDDDFQL

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.06

EPEELAQLAPTPGDAIISLD

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.1

EPEELAQLAPTPGDAIISLD

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.001

hypoxia-inducible factor-L-proline

Homo sapiens

-

C-terminal oxygen degradation domain DLDLEALAP564YIPADDDFQL mutant M561A/M568A in absence of NaCl, pH 7.0, 37°C

725653

0.0042

hypoxia-inducible factor-L-proline

Homo sapiens

-

C-terminal oxygen degradation domain DLDLEALAP564YIPADDDFQL mutant M561A/M568A in presence of 100 mM NaCl, pH 7.0, 37°C

725653

0.011

hypoxia-inducible factor-L-proline

Homo sapiens

-

N-terminal oxygen degradation domain DALTLLAP402AAGDTIISLDYG mutant F413Y in presence of 100 mM NaCl, pH 7.0, 37°C

725653

0.014

hypoxia-inducible factor-L-proline

Homo sapiens

-

N-terminal oxygen degradation domain DALTLLAP402AAGDTIISLDYG mutant F413Y in absence of NaCl, pH 7.0, 37°C

725653

0.067

hypoxia-inducible factor-L-proline

Homo sapiens

-

recombinant enzyme, pH 7.0, 37°C

726084

0.000016

hypoxia-inducible factor1alpha C-terminal oxygen-dependent degradation domain-L-proline

Homo sapiens

Q96KS0, Q9GZT9, Q9H6Z9

pH 7.5, 25°C, PHD3

724225

-

0.00075 - 0.00094

hypoxia-inducible factor1alpha C-terminal oxygen-dependent degradation domain-L-proline

Homo sapiens

Q96KS0, Q9GZT9, Q9H6Z9

pH 7.5, 25°C, PHD2

724225

-

0.1

O2

Homo sapiens

Q9GZT9

mutant enzyme T387A, at pH 7.0 and 37°C

741910

0.23

O2

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.25

O2

Homo sapiens

Q9GZT9, Q9H6Z9

pH 7.8, 37°C

659235

0.53

O2

Homo sapiens

Q9GZT9

wild type isoform PHD2, at pH 7.0 and 37°C

741910

0.76

O2

Homo sapiens

Q9GZT9

mutant enzyme T387N, at pH 7.0 and 37°C

741910

additional information

additional information

Homo sapiens

-

kinetics, overview

726084

-

additional information

additional information

Homo sapiens

Q96KS0

steady-state kinetic analysis and substrate selectivity for hypoxia-inducible factor and 2-oxoglutarate

724225

-

additional information

additional information

Homo sapiens

Q9GZT9

steady-state kinetic analysis and substrate selectivity for hypoxia-inducible factor and 2-oxoglutarate

724225

-

additional information

additional information

Homo sapiens

Q9H6Z9

steady-state kinetic analysis and substrate selectivity for hypoxia-inducible factor and 2-oxoglutarate

724225

-