1.14.11.29: hypoxia-inducible factor-proline dioxygenase

This is an abbreviated version!
For detailed information about hypoxia-inducible factor-proline dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.29

1.14.11.29

hydroxylases

endothelial

erythropoietin

anemia

oxygen-dependent

hippel-lindau

factor-1

normoxic

altitude

dioxygenases

tetrahydrobiopterin

oxygen-sensing

erythrocytosis

high-altitude

bh4

tibetan

cyclohydrolase

hif-mediated

eglns

asparaginyl

2-oxoglutarate-dependent

highland

hifalpha

paragangliomas

hepcidin

hypoxia-responsive

hif-independent

andeans

polycythemia

roxadustat

dmog

hypoxia-sensing

gtp-cyclohydrolase

erythropoiesis-stimulating

drug development

pharmacology

medicine

Reaction

hypoxia-inducible factor-(4R)-4-hydroxy-L-proline

Synonyms

Egl nine homolog 1, EGLN, EGLN1, Egln2, EGLN3, factor inhibiting HIF, FIH, HIF hydroxylase, HIF prolyl, HIF prolyl 4-hydroxylase, HIF prolyl hydroxylase, HIF-1alpha PHD3, HIF-1alpha prolyl hydroxylase 3, HIF-alpha prolyl-hydroxylase, HIF-P4H-1, HIF-P4H-2, HIF-P4H-3, HIF-PH, Hif-prolyl hydroxylase, HIF-prolyl hydroxylase domain 2, HIF-prolyl hydroxylase-2, HPH-1, HPH-2, HPH-3, hydroxylase domain enzyme, hypoxia-inducible factor prolyl hydroxylase 2, hypoxia-inducible factor prolyl hydroxylase domain 2, P4H-TM, PHD, PHD1, PHD2, PHD3, proline hydroxylase domain 2, prolyl 4-hydroxylase, prolyl hydroxylase, prolyl hydroxylase domain, prolyl hydroxylase domain protein, prolyl hydroxylase domain protein 2, prolyl hydroxylase-2, prolyl-4-hydroxylase 2, prolyl-4-hydroxylase domain 2, transmembrane prolyl 4-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.29 hypoxia-inducible factor-proline dioxygenase

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Results	in table
10	Activating Compound
35	AA Sequence
6	Application
19	Cloned(Commentary)
5	Crystallization (Commentary)
803	Disease/ Diagnostics
4	Expression
43	General Information
66	IC50 Value
143	Inhibitors
13	kcat/KM [mM/s]
23	Ki Value [mM]
61	KM Value [mM]
1	Localization
14	Metals/Ions
3	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
62	Organism
59	PDB ID
5	pH Optimum
11	Protein Variants
11	Purification (Commentary)
1	Reaction
52	Reference
68	Source Tissue
99	Substrates and Products (Substrate)
5	Subunits
131	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
16	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.14.11.29 - hypoxia-inducible factor-proline dioxygenase

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0.0026

(2R)-[2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido](phenyl)acetic acid

Homo sapiens

pH and temperature not specified in the publication

742072

0.0028

(2S)-[2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido](phenyl)acetic acid

Homo sapiens

pH and temperature not specified in the publication

742072

0.0295 - 0.0397

1,1',1'',1'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetrapropan-2-ol

2 entries

0.0309

2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide

Homo sapiens

recombinant enzyme, pH 7.0, 37°C

726084

0.005

2,3-dihydroxypyridine

Homo sapiens

pH 7.0, 37°C

725647

0.0004

2-(2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-methylthiazol-4-yl)-N-(2-(diethylamino)ethyl)acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.0057

2-(2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-phenylthiazol-4-yl)-N-(2-(pyridin-2-yl)ethyl)acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.024

2-(2-(5-cyano-3-hydroxypyridin-2-yl)-5-phenylthiazol-4-yl)-N-(2-(pyridin-2-yl)ethyl)acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.003

2-hydroxypyridine 1-oxide

Homo sapiens

pH 7.0, 37°C

725647

0.0038

2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-1,3-thiazol-4-yl]-N-[2-(diethylamino)ethyl]acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.0007

2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.0014

2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-methyl-1,3-thiazol-4-yl]-N-propylacetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.0008

2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-methyl-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.0034

2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-(2-phenylethyl)acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.0021

2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-[(1R)-2-hydroxy-1-phenylethyl]acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.0024

2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-[(1S)-2-hydroxy-1-phenylethyl]acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.003

2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.0012

2-[2-(5-cyano-3-hydroxypyridin-2-yl)-5-methyl-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.0073

2-[2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido]-2-methylpropanoic acid

Homo sapiens

pH and temperature not specified in the publication

742072

0.0604

3,3'-[(pyridin-2-ylmethyl)imino]dipropanenitrile

Homo sapiens

recombinant enzyme, pH 7.0, 37°C

725644

0.0128

3,3'-[(pyridin-4-ylimino)bis(propane-3,1-diyliminomethanediyl)]diphenol

Homo sapiens

recombinant enzyme, pH 7.0, 37°C

725644

0.016

3,3'-[(pyridin-4-ylimino)bis[propane-3,1-diylnitrilo(Z)methylylidene]]diphenol

Homo sapiens

recombinant enzyme, pH 7.0, 37°C

725644

0.0103

3,6,9-tris(naphthalen-1-ylmethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene

Homo sapiens

recombinant enzyme, pH 7.0, 37°C

726084

0.000253

3-([1,1'-biphenyl]-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-1-(pyrimidin-2-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione

Homo sapiens

Q9GZT9

pH not specified in the publication, temperature not specified in the publication

764504

3-cyano-6-methyl-2(H)-pyridinone

Homo sapiens

above, pH 7.0, 37°C

725647

0.04

3-hydroxy-1,2-dimethyl-4(1H)-pyridinone

Homo sapiens

pH 7.0, 37°C

725647

3-hydroxy-2-methyl-4-pyrone

Homo sapiens

above, pH 7.0, 37°C

725647

0.00224

3-[(1,3-benzoxazol-2-yl)carbamoyl]propanoic acid

Homo sapiens

Q9GZT9

pH 7.8, temperature not specified in the publication

765314

0.00132

3-[(5-chloro-1,3-benzoxazol-2-yl)carbamoyl]propanoic acid

Homo sapiens

Q9GZT9

pH 7.8, temperature not specified in the publication

765314

0.000153

4-hydroxy-2-(1H-pyrazol-1-yl)-N-[[4-(trifluoromethyl)phenyl]methyl]pyrimidine-5-carboxamide

Homo sapiens

Q9GZT9

pH not specified in the publication, temperature not specified in the publication

764504

0.000093

4-hydroxy-N-[(1R)-2-hydroxy-1-phenylethyl]-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide

Homo sapiens

Q9GZT9

pH not specified in the publication, temperature not specified in the publication

764504

0.000256

4-hydroxy-N-[(4-phenoxyphenyl)methyl]-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide

Homo sapiens

Q9GZT9

pH not specified in the publication, temperature not specified in the publication

764504

0.004

4-methylcatechol

Homo sapiens

pH 7.0, 37°C

725647

0.006

4-nitrocatechol

Homo sapiens

pH 7.0, 37°C

725647

0.03

4-tert-butylcatechol

Homo sapiens

pH 7.0, 37°C

725647

0.4

5-hydroxy-2-hydroxymethyl-4-pyrone

Homo sapiens

pH 7.0, 37°C

725647

0.03

5-hydroxy-4-oxo-4H-pyran-2-carboxylic acid

Homo sapiens

pH 7.0, 37°C

725647

0.002

5-hydroxy-6-[4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1,3-thiazol-2-yl]pyridine-3-carbonitrile

Homo sapiens

pH and temperature not specified in the publication

742072

0.0000048

6-[5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl]pyridine-3-carboxylic acid

Homo sapiens

Q96KS0, Q9GZT9, Q9H6Z9

isoform PHD2, pH and temperature not specified in the publication

743581

0.0244 - 0.1425

CO releasing molecule-2

4 entries

0.0039

FG-2216

Homo sapiens

pH and temperature not specified in the publication

742072

0.00221

FG-4592

Homo sapiens

Q9GZT9

pH 7.8, temperature not specified in the publication

765314

0.0207

N,N-dimethyl-5-[3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-6-ylsulfonyl]naphthalen-1-amine

Homo sapiens

recombinant enzyme, pH 7.0, 37°C

726084

0.000013

N-(1-[[6-(4-chlorophenoxy)pyridin-3-yl]methyl]-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonyl)glycine

Homo sapiens

Q9GZT9

pH not specified in the publication, temperature not specified in the publication

764289

0.000049

N-(4-hydroxy-1-[[4-(4-methylphenoxy)phenyl]methyl]-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonyl)glycine

Homo sapiens

Q9GZT9

pH not specified in the publication, temperature not specified in the publication

764289

0.000069

N-(4-hydroxy-1-[[5-(4-methylphenoxy)pyridin-2-yl]methyl]-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonyl)glycine

Homo sapiens

Q9GZT9

pH not specified in the publication, temperature not specified in the publication

764289

0.000039

N-(4-hydroxy-1-[[6-(4-methylphenoxy)pyridin-3-yl]methyl]-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonyl)glycine

Homo sapiens

Q9GZT9

pH not specified in the publication, temperature not specified in the publication

764289

0.000213

N-([1,1'-biphenyl]-4-yl)-4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide

Homo sapiens

Q9GZT9

pH not specified in the publication, temperature not specified in the publication

764504

0.081

N-benzyl-2-[2-(3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.0054

N-benzyl-2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamide

Homo sapiens

pH and temperature not specified in the publication

742072

0.0000022

N-oxalylglycine

2 entries

0.000261

N-[(1,3-dihydro-2-benzofuran-5-yl)methyl]-4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide

Homo sapiens

Q9GZT9

pH not specified in the publication, temperature not specified in the publication

764504

0.00021

N-[([1,1'-biphenyl]-4-yl)methyl]-4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide

Homo sapiens

Q9GZT9

pH not specified in the publication, temperature not specified in the publication

764504

0.0000016

tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate

2 entries

0.000022

[(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino]acetic acid

Homo sapiens

Q96KS0, Q9GZT9, Q9H6Z9

isoform PHD2, pH and temperature not specified in the publication

743581

0.195

[2-(3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetic acid

Homo sapiens

pH and temperature not specified in the publication

742072

0.0275

[2-(3-hydroxypyridin-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl]acetic acid

Homo sapiens

pH and temperature not specified in the publication

742072

0.006

[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetic acid

Homo sapiens

pH and temperature not specified in the publication

742072

0.0135

[2-(5-cyano-3-hydroxypyridin-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl]acetic acid

Homo sapiens

pH and temperature not specified in the publication

742072

0.0022

[2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido]acetic acid

Homo sapiens

pH and temperature not specified in the publication

742072