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1.14.11.27: [histone H3]-dimethyl-L-lysine36 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-dimethyl-L-lysine36 demethylase, go to the full flat file.

Word Map on EC 1.14.11.27

Reaction

a [histone H3]-N6,N6-dimethyl-L-lysine36
+ 2 2-oxoglutarate + 2 O2 =
a [histone H3]-L-lysine36
+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

dKDM2, dKDM4A, dRAF, GASC1, H3-K36 demethylase, H3-K36-specific demethylase, H3K36 demethylase, H3K36me2 demethylase, H3K36me2 histone demethylase, H3K36me2-specific demethylase, histone H3 lysine 36 demethylase, histone H3 lysine 36 dimethylspecific demethylase, histone-lysine(H3-K36) demethylase, Jhd1, JHDM1A, Jhdm1b/Kdm2b, JmjC domain histone demethylase, JmjC domain-containing histone demethylase 1, JmjC domain-containing histone demethylase 1A, JmjC domain-containing histone demethylation protein 1, JMJD2, JMJD2A, JMJD5, JMJD7, Kdm2a, KDM2B, KDM2b/JHDM1b, KDM4, KDM4A, KDM4B, Kdm4c, KDM4D, KDM8, lysine demethylase, More, Ndy1, PfJmjC1, PfSET1, scJHDM1, SET1, [histone-H3]-lysine-36 demethylase 1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.27 [histone H3]-dimethyl-L-lysine36 demethylase

Localization

Localization on EC 1.14.11.27 - [histone H3]-dimethyl-L-lysine36 demethylase

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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
isozyme KDM4C is associated with chromatin during mitosis, residue R919 on the proximal Tudor domains of KDM4C is critical for its association with chromatin during mitosis. KDM4C protein is localized to mitotic chromatin from prometaphase to telophase
Manually annotated by BRENDA team
additional information