1.14.11.26: deacetoxycephalosporin-C hydroxylase

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For detailed information about deacetoxycephalosporin-C hydroxylase, go to the full flat file.

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Synonyms

cefF, Cephalosporin biosynthesis expandase/hydroxylase, DACS, DAOC hydroxylase, DAOC synthase, DAOC/DAC synthase, DAOCS, deacetoxycephalosporin C hydroxylase, deacetoxycephalosporin C synthase, deacetylcephalosporin C synthase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.26 deacetoxycephalosporin-C hydroxylase

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Results	in table
9	Activating Compound
32	AA Sequence
2	Application
2	CAS Registry Number
7	Cloned(Commentary)
14	General Information
1	General Stability
31	Inhibitors
6	kcat/KM [mM/s]
1	Ki Value [mM]
47	KM Value [mM]
1	Localization
11	Metals/Ions
8	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
20	Organism
4	Pathway
4	pH Optimum
1	pH Stability
3	pI Value
85	Protein Variants
7	Purification (Commentary)
1	Reaction
3	Reaction Type
20	Reference
1	Renatured (Commentary)
1	Specific Activity [micromol/min/mg]
2	Storage Stability
31	Substrates and Products (Substrate)
5	Subunits
18	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
42	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.11.26 - deacetoxycephalosporin-C hydroxylase

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SYSTEMATIC NAME

IUBMB Comments

deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Requires iron(II). The enzyme can also use 3-exomethylenecephalosporin C as a substrate to form deacetoxycephalosporin C, although more slowly [2]. In Acremonium chrysogenum, the enzyme forms part of a bifunctional protein along with EC 1.14.20.1, deactoxycephalosporin-C synthase. It is a separate enzyme in Streptomyces clavuligerus.