1.14.11.26: deacetoxycephalosporin-C hydroxylase

This is an abbreviated version!
For detailed information about deacetoxycephalosporin-C hydroxylase, go to the full flat file.

Word Map on EC 1.14.11.26

1.14.11.26

clavuligerus

penicillin

dithiothreitol

ascorbate

acremonium

alpha-ketoglutarate

chrysogenum

ring-expansion

n-ethylmaleimide

expandase

cephalosporium

synthesis

biotechnology

Reaction

Synonyms

cefF, Cephalosporin biosynthesis expandase/hydroxylase, DACS, DAOC hydroxylase, DAOC synthase, DAOC/DAC synthase, DAOCS, deacetoxycephalosporin C hydroxylase, deacetoxycephalosporin C synthase, deacetylcephalosporin C synthase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.26 deacetoxycephalosporin-C hydroxylase

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Results	in table
9	Activating Compound
32	AA Sequence
2	Application
2	CAS Registry Number
7	Cloned(Commentary)
14	General Information
1	General Stability
31	Inhibitors
6	kcat/KM [mM/s]
1	Ki Value [mM]
47	KM Value [mM]
1	Localization
11	Metals/Ions
8	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
20	Organism
4	Pathway
4	pH Optimum
1	pH Stability
3	pI Value
85	Protein Variants
7	Purification (Commentary)
1	Reaction
3	Reaction Type
20	Reference
1	Renatured (Commentary)
1	Specific Activity [micromol/min/mg]
2	Storage Stability
31	Substrates and Products (Substrate)
5	Subunits
18	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
42	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.14.11.26 - deacetoxycephalosporin-C hydroxylase

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(2S,4S,6R,7R)-1-aza-7-((5R)-5-carboxypentanamidol)-4-methyl-8-oxo-5-thiatricyclo-(4,2,0,0)octane-2-carboxylate

Acremonium chrysogenum

reversible, 0.04 mM, 90% inhibition

660936

5,5'-dithiobis-2-nitrobenzoic acid

3 entries

ammonium hydrogencarbonate

Acremonium chrysogenum

100-500 mM, complete inactivation

660936

ampicillin

Streptomyces clavuligerus

440380

bathophenanthroline

Acremonium chrysogenum

660936

Ca2+

Acremonium chrysogenum

weak

661974

Co2+

Streptomyces clavuligerus

inhibition in decreasing order, Zn2+, Co2+, Ni2+

EDTA

iodoacetic acid

N-ethylmaleimide

Ni2+

Streptomyces clavuligerus

inhibition in decreasing order, Zn2+, Co2+, Ni2+

440380

o-phenanthroline

3 entries

p-hydroxymercuribenzoate

3 entries

penicillin G

Streptomyces clavuligerus

440380

Penicillin N

Streptomyces clavuligerus

1 mM, 62% inhibition, competitive with deacetoxycephalosporin C

662088

Penicillin V

Streptomyces clavuligerus

440380

Zn2+

2 entries