1.13.12.3: tryptophan 2-monooxygenase

This is an abbreviated version!
For detailed information about tryptophan 2-monooxygenase, go to the full flat file.

Word Map on EC 1.13.12.3

1.13.12.3

flavoproteins

indole-3-acetic

indoleacetamide

savastanoi

indole-3-acetamide

indoleacetic

l-amino

gall

rhizogenes

indolepyruvate

oleander

Reaction

L-tryptophan

+

O2

=

(indol-3-yl)acetamide

+

CO2

+

H2O

Synonyms

IaaM, oxygenase, tryptophan 2-mono-, Pgt-IaaM, PGTG_11658, TMO, tryptophan 2-monooxygenase, tryptophan monooxygenase

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

1.13.12.3 tryptophan 2-monooxygenase

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Results	in table
396	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
4	Expression
13	General Information
1	General Stability
42	Inhibitors
5	kcat/KM [mM/s]
12	Ki Value [mM]
25	KM Value [mM]
3	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
23	Organism
5	Pathway
2	PDB ID
4	pH Optimum
2	pH Range
10	Protein Variants
4	Purification (Commentary)
1	Reaction
4	Reaction Type
21	Reference
3	Specific Activity [micromol/min/mg]
4	Storage Stability
32	Substrates and Products (Substrate)
1	Subunits
15	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
16	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.13.12.3 - tryptophan 2-monooxygenase

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2-mercaptoethanol

Pseudomonas savastanoi

-

weak

2-methyl methanethiolsulfonate

Pseudomonas savastanoi

-

-

2-Oxo-3-pentynoate

Pseudomonas savastanoi

-

-

3-Indoleacetamide

Pseudomonas savastanoi

-

-

3-indolepyruvate

Pseudomonas savastanoi

-

-

BaCl2

Pseudomonas savastanoi

-

weak

CaCl2

Pseudomonas savastanoi

-

little or no effect

CuCl2

Pseudomonas savastanoi

-

-

D-methionine

Pseudomonas savastanoi

-

competitive inhibition

D-phenylalanine

Pseudomonas savastanoi

-

competitive inhibition

D-tryptophan

show

diethylpyrocarbonate

Pseudomonas savastanoi

-

-

diethylthiocarbonate

Pseudomonas savastanoi

-

-

EDTA

Pseudomonas savastanoi

-

little or no effect

HgCl2

Pseudomonas savastanoi

-

-

Hydrocinnamic acid

Pseudomonas savastanoi

-

competitive inhibition

hydroxylamine

Pseudomonas savastanoi

-

-

Indole-3-acetaldehyde

Pseudomonas savastanoi

-

weak

Indole-3-acetamide

show

indole-3-acetic acid

Pseudomonas savastanoi

-

-

439341, 439343, 439347

Indole-3-pyruvate

Pseudomonas savastanoi

-

-

iodoacetamide

Pseudomonas savastanoi

-

-

isoniazid

Pseudomonas savastanoi

-

-

K3Fe(CN)6

Pseudomonas savastanoi

-

weak

KCN

Pseudomonas savastanoi

-

little or no effect

L-cysteine

Pseudomonas savastanoi

-

-

L-glutathione

Pseudomonas savastanoi

-

reduced

N-ethylmaleimide

Pseudomonas savastanoi

-

-

phenylacetamide

Pseudomonas savastanoi

-

competitive inhibition

Phenylethylamine

Pseudomonas savastanoi

-

competitive inhibition

phenyllactic acid

Pseudomonas savastanoi

-

competitive inhibition

phenylpyruvic acid

Pseudomonas savastanoi

-

competitive inhibition

Quinacrine

Pseudomonas savastanoi

-

weak

Semicarbazide

Pseudomonas savastanoi

-

-

tryptamine

Pseudomonas savastanoi

-

competitive inhibition

Vinylglycine

Pseudomonas savastanoi

-

-

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Release 2023.1 (January 2023)