1.13.12.3: tryptophan 2-monooxygenase
This is an abbreviated version!
For detailed information about tryptophan 2-monooxygenase, go to the full flat file.
Word Map on EC 1.13.12.3
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1.13.12.3
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flavoproteins
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indole-3-acetic
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indoleacetamide
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savastanoi
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indole-3-acetamide
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indoleacetic
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l-amino
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gall
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rhizogenes
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indolepyruvate
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oleander
- 1.13.12.3
- flavoproteins
-
indole-3-acetic
-
indoleacetamide
- savastanoi
- indole-3-acetamide
-
indoleacetic
-
l-amino
- gall
- rhizogenes
- indolepyruvate
-
oleander
Reaction
Synonyms
IaaM, oxygenase, tryptophan 2-mono-, Pgt-IaaM, PGTG_11658, TMO, tryptophan 2-monooxygenase, tryptophan monooxygenase
ECTree
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Engineering
Engineering on EC 1.13.12.3 - tryptophan 2-monooxygenase
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K365M
mutation decreases the kcat and kcat/Km (L-tryptophan) values by 60000- and 2 millionfold compared to wild-type, respectively
W466F
mutation decreases the kcat value less than 2fold and the kcat/Km (L-tryptophan) value only 5fold compared to wild-type
W466M
mutation results in an enzyme lacking flavin and detectable activity
Y413A
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200fold reduction in first-order rate constant for reduction, 33fold decrease in rate constant for oxidation, conversion of enzyme to oxidase
Y413F
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35fold reduction in first-order rate constant for reduction, 11fold decrease in rate constant for oxidation, conversion of enzyme to oxidase