1.13.12.17: dichloroarcyriaflavin A synthase
This is an abbreviated version!
For detailed information about dichloroarcyriaflavin A synthase, go to the full flat file.
Reaction
+ 4 O2 + 4 NADH + 4 H+ = + 2 CO2 + 6 H2O + 4 NAD+
Synonyms
CYP245A1, cytochrome P450 StaP, P450 StaP, StaP
ECTree
Advanced search results
Reference
Reference on EC 1.13.12.17 - dichloroarcyriaflavin A synthase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Howard-Jones, A.R.; Walsh, C.T.
Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid
J. Am. Chem. Soc.
128
12289-12298
2006
Streptomyces longisporoflavus (Q06IS2)
Howard-Jones, A.R.; Walsh, C.T.
Nonenzymatic oxidative steps accompanying action of the cytochrome P450 enzymes StaP and RebP in the biosynthesis of staurosporine and rebeccamycin
J. Am. Chem. Soc.
129
11016-11007
2007
Streptomyces longisporoflavus (Q06IS2)
Wang, Y.; Hirao, H.; Chen, H.; Onaka, H.; Nagano, S.; Shaik, S.
Electron transfer activation of chromopyrrolic acid by cytochrome P450 en route to the formation of an antitumor indolocarbazole derivative: theory supports experiment
J. Am. Chem. Soc.
130
7170-7171
2008
Streptomyces longisporoflavus
Wang, Y.; Chen, H.; Makino, M.; Shiro, Y.; Nagano, S.; Asamizu, S.; Onaka, H.; Shaik, S.
Theoretical and experimental studies of the conversion of chromopyrrolic acid to an antitumor derivative by cytochrome P450 StaP: the catalytic role of water molecules
J. Am. Chem. Soc.
131
6748-6762
2009
Streptomyces longisporoflavus
Sanchez, C.; Zhu, L.; Brana, A.F.; Salas, A.P.
Rohr, J.; Mendez, C.; Salas, J.A.: Combinatorial biosynthesis of antitumor indolocarbazole compounds
Proc. Natl. Acad. Sci. USA
102
461-466
2004
Streptomyces albus
Makino, M.; Sugimoto, H.; Shiro, Y.; Asamizu, S.; Onaka, H.; Nagano, S.
Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton
Proc. Natl. Acad. Sci. USA
104
11591-11596
2007
Streptomyces sp. (Q83WG3), Streptomyces sp. TP-A0274 (Q83WG3)
html completed