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1.13.12.17: dichloroarcyriaflavin A synthase

This is an abbreviated version!
For detailed information about dichloroarcyriaflavin A synthase, go to the full flat file.

Reaction

dichlorochromopyrrolate
+ 4 O2 + 4 NADH + 4 H+ =
dichloroarcyriaflavin A
+ 2 CO2 + 6 H2O + 4 NAD+

Synonyms

CYP245A1, cytochrome P450 StaP, P450 StaP, StaP

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
                1.13.12.17 dichloroarcyriaflavin A synthase

Reference

Reference on EC 1.13.12.17 - dichloroarcyriaflavin A synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Howard-Jones, A.R.; Walsh, C.T.
Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid
J. Am. Chem. Soc.
128
12289-12298
2006
Streptomyces longisporoflavus (Q06IS2)
Manually annotated by BRENDA team
Howard-Jones, A.R.; Walsh, C.T.
Nonenzymatic oxidative steps accompanying action of the cytochrome P450 enzymes StaP and RebP in the biosynthesis of staurosporine and rebeccamycin
J. Am. Chem. Soc.
129
11016-11007
2007
Streptomyces longisporoflavus (Q06IS2)
Manually annotated by BRENDA team
Wang, Y.; Hirao, H.; Chen, H.; Onaka, H.; Nagano, S.; Shaik, S.
Electron transfer activation of chromopyrrolic acid by cytochrome P450 en route to the formation of an antitumor indolocarbazole derivative: theory supports experiment
J. Am. Chem. Soc.
130
7170-7171
2008
Streptomyces longisporoflavus
Manually annotated by BRENDA team
Wang, Y.; Chen, H.; Makino, M.; Shiro, Y.; Nagano, S.; Asamizu, S.; Onaka, H.; Shaik, S.
Theoretical and experimental studies of the conversion of chromopyrrolic acid to an antitumor derivative by cytochrome P450 StaP: the catalytic role of water molecules
J. Am. Chem. Soc.
131
6748-6762
2009
Streptomyces longisporoflavus
Manually annotated by BRENDA team
Sanchez, C.; Zhu, L.; Brana, A.F.; Salas, A.P.
Rohr, J.; Mendez, C.; Salas, J.A.: Combinatorial biosynthesis of antitumor indolocarbazole compounds
Proc. Natl. Acad. Sci. USA
102
461-466
2004
Streptomyces albus
Manually annotated by BRENDA team
Makino, M.; Sugimoto, H.; Shiro, Y.; Asamizu, S.; Onaka, H.; Nagano, S.
Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton
Proc. Natl. Acad. Sci. USA
104
11591-11596
2007
Streptomyces sp. (Q83WG3), Streptomyces sp. TP-A0274 (Q83WG3)
Manually annotated by BRENDA team