1.13.12.17: dichloroarcyriaflavin A synthase
This is an abbreviated version!
For detailed information about dichloroarcyriaflavin A synthase, go to the full flat file.
Reaction
+ 4 O2 + 4 NADH + 4 H+ = + 2 CO2 + 6 H2O + 4 NAD+
Synonyms
CYP245A1, cytochrome P450 StaP, P450 StaP, StaP
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.13.12.17 - dichloroarcyriaflavin A synthase
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REACTION DIAGRAM
dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+
1,11-dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
the reaction is catalyzed by enzyme StaP. StaC and RebC acting to direct the level of oxidation in the newly formed five-membered ring. Biosynthesis of the antitumor indolocarbazoles rebeccamycin and staurosporine by streptomycetes
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dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+
dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
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dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+
dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
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chromopyrrolic acid oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs
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dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+
dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
staurosporine biosynthesis
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dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+
dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
staurosporine biosynthesis
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