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1.13.12.17: dichloroarcyriaflavin A synthase

This is an abbreviated version!
For detailed information about dichloroarcyriaflavin A synthase, go to the full flat file.

Reaction

dichlorochromopyrrolate
+ 4 O2 + 4 NADH + 4 H+ =
dichloroarcyriaflavin A
+ 2 CO2 + 6 H2O + 4 NAD+

Synonyms

CYP245A1, cytochrome P450 StaP, P450 StaP, StaP

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
                1.13.12.17 dichloroarcyriaflavin A synthase

Natural Substrates Products

Natural Substrates Products on EC 1.13.12.17 - dichloroarcyriaflavin A synthase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+
1,11-dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
show the reaction diagram
the reaction is catalyzed by enzyme StaP. StaC and RebC acting to direct the level of oxidation in the newly formed five-membered ring. Biosynthesis of the antitumor indolocarbazoles rebeccamycin and staurosporine by streptomycetes
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-
?
dichlorochromopyrrolate + 4 O2 + 4 NADH + 4 H+
dichloroarcyriaflavin A + 2 CO2 + 6 H2O + 4 NAD+
show the reaction diagram