1.13.12.13: Oplophorus-luciferin 2-monooxygenase
This is an abbreviated version!
For detailed information about Oplophorus-luciferin 2-monooxygenase, go to the full flat file.
Word Map on EC 1.13.12.13
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1.13.12.13
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bioluminescence
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luminescence
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firefly
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luciferases
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gracilirostris
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nanobit
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furimazine
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lgbit
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renilla
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brightest
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coelenterazine
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gaussia
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molecular biology
- 1.13.12.13
-
bioluminescence
-
luminescence
- firefly
- luciferases
- gracilirostris
-
nanobit
- furimazine
-
lgbit
- renilla
-
brightest
- coelenterazine
- gaussia
- molecular biology
Reaction
Synonyms
19kOLase, CXXC-Oluc, imidazopyrazinone-type luciferase, KAZ, luciferase, nanoKAZ, NanoLuc, Oluc-19, Oplophorus luciferase
ECTree
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Subunits
Subunits on EC 1.13.12.13 - Oplophorus-luciferin 2-monooxygenase
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heterooligomer
Q9GV45; Q9GV46
x * 19000, catalytic subunit, + x * 35000, noncatalytic subunit, SDS-PAGE
additional information
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enzyme consists of 19 and 35 kDa proteins. Luminescence intensity of the catalytic subunit 19kOLase alone is seven times lower for coelenterazine and three times lower for biscoelenterazine than that of native Oplophorus luciferase, respectively
additional information
Q9GV45; Q9GV46
the structure of the mutant catalytic subunit nanoKAZ consists of 11 antiparallel beta-strands forming a beta-barrel that is capped by 4 short alpha-helices. The coelenterazine-binding site and the catalytic site for the luminescence reaction might be in a central cavity of the beta-barrel structure of the catalytic subunit KAZ