1.13.11.79: aerobic 5,6-dimethylbenzimidazole synthase

This is an abbreviated version!
For detailed information about aerobic 5,6-dimethylbenzimidazole synthase, go to the full flat file.

Reaction

Synonyms

BluB, bluB/cobT2, DMB-synthase, EC 1.14.99.40, flavin destructase, flavin destructase enzyme

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.79 aerobic 5,6-dimethylbenzimidazole synthase

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Results	in table
2849	AA Sequence
5	Cloned(Commentary)
2	Cofactor
8	General Information
1	Inhibitors
1	Ki Value [mM]
4	KM Value [mM]
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
12	Organism
5	Pathway
1	pH Optimum
19	Protein Variants
3	Purification (Commentary)
2	Reaction
12	Reference
14	Substrates and Products (Substrate)
3	Subunits
20	Synonyms
1	Systematic Name
3	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.13.11.79 - aerobic 5,6-dimethylbenzimidazole synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

FMNH2 + NADH + H+ + O2

5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + ?

Sinorhizobium meliloti

Q92PC8

-

728760

5,6-dimethylbenzimidazole is the lower axial ligand of vitamin B12, i.e. cobalamin

-

?

FMNH2 + NADH + H+ + O2 + alloxan

5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + dialuric acid

Sinorhizobium meliloti

-

-

715295

-

-

?

FMNH2 + O2

5,6-dimethylbenzimidazole + ?

2 entries

FMNH2 + O2

5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialiric acid + pyrimidinetrione + alloxan

Sinorhizobium meliloti

-

the rate of formation of the intermediate product unprotonated C4a-peroxyflavin is influenced by substitutions at C8 of FMN

764145

-

-

?

FMNH2 + O2

5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + urea + ?

2 entries

FMNH2 + O2

5,6-dimethylbenzimidazole + ?

Sinorhizobium meliloti

-

FMNH2 reacts with oxygen to yield flavin hydroperoxide, which then undergoes a ring expansion with loss of a water molecule to produce intermediate A. This disintegrates further as a result of four hydrolysis reactions in which it is attacked by water molecules. The resulting diaminobenzene product undergoes two oxidation reactions, to form 5,6-dimethylbenzimidazole

730461

-

-

?

FMNH2 + O2

5,6-dimethylbenzimidazole + ?

Trichodesmium sp.

-

-

764756

-

-

?

FMNH2 + O2

5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + urea + ?

Priestia megaterium

-

-

728590

-

-

?

FMNH2 + O2

5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + urea + ?

Rhodobacter capsulatus

-

-

728590

-

-

?