1.13.11.72: 2-hydroxyethylphosphonate dioxygenase
This is an abbreviated version!
For detailed information about 2-hydroxyethylphosphonate dioxygenase, go to the full flat file.
Reaction
Synonyms
HEPD, hydroxyethylphosphonate dioxygenase, PhdP, phpD
ECTree
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Reaction
Reaction on EC 1.13.11.72 - 2-hydroxyethylphosphonate dioxygenase
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2-hydroxyethylphosphonate + O2 = hydroxymethylphosphonate + formate
catalytic mechanism
2-hydroxyethylphosphonate + O2 = hydroxymethylphosphonate + formate
initial substrate oxidation by a ferric-superoxo-intermediate and a second oxidation by a ferryl species, catalytic mechanism, detailed overview
2-hydroxyethylphosphonate + O2 = hydroxymethylphosphonate + formate
the reaction proceeds via a transient iron(IV)-oxo (ferryl) complex, a mechanism that involves activation of an O-H bond by the ferryl complex is proposed. The isotope-sensitive C-H-cleavage step is not primarily rate-limiting for the overall catalytic cycle. The reaction does exhibit a significant 2H-kinetic isotope effect on kcat/Km for O2, which implies reversible formation of the C-H-cleaving intermediate
2-hydroxyethylphosphonate + O2 = hydroxymethylphosphonate + formate
catalytic mechanism
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-
2-hydroxyethylphosphonate + O2 = hydroxymethylphosphonate + formate
the reaction proceeds via a transient iron(IV)-oxo (ferryl) complex, a mechanism that involves activation of an O-H bond by the ferryl complex is proposed. The isotope-sensitive C-H-cleavage step is not primarily rate-limiting for the overall catalytic cycle. The reaction does exhibit a significant 2H-kinetic isotope effect on kcat/Km for O2, which implies reversible formation of the C-H-cleaving intermediate
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-
2-hydroxyethylphosphonate + O2 = hydroxymethylphosphonate + formate
initial substrate oxidation by a ferric-superoxo-intermediate and a second oxidation by a ferryl species, catalytic mechanism, detailed overview
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