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immunostaining of CMO1 in the A549 cells, overview
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human kidney cell line
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of skin squamous epithelium
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pectoralis major
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predominantly expressed in ocellus photoreceptor cells of the larva
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enzyme is highly expressed in retinal pigment epithelium
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adult and embryonic, very low Bco1 expression level
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intestinal cell line Caco-2/subclone TC7
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when TC7 cells are maintained in serum-free medium, activity is increased 8.2fold after 19 days of postconfluence
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in epithelial cells of the mucosa, quantitative RT-PCR expression analysis, and in situ hybridization
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mRNA is abundant at embryonic day 7, with lower expression at embryonic days 11, 13 and 15
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of several tissues including stomach, intestine, colon, prostate glands, and endometrium
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of several tissues including stomach, intestine, colon, prostate glands, and endometrium
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of several tissues including stomach, intestine, colon, prostate glands, and endometrium
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expression is eye-dependent
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beta-carotene-15,15'-dioxygenase (BCO1) protein is not expressed in adult hearts of male wild-type mice
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mucosa
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mucosa
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mucosa
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mucosa
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Domania subtryug
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mucosa
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mucosa
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highest expression in duodenum, mRNA level in ileum is markedly low
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mucosa
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high levels of BCO mRNA, highest level in jejunum
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activity detected in two subclones of Caco-2, PF11 and TC7. When TC7 cells are maintained in serum-free medium, activity is increased 8.2fold after 19 days of postconfluence. No activity detected in IPEC-1, HepG2, HL60, Wurzburg, or parent Caco-2, PF11 and TC7
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mucosa
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mucosa
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pylorus to the lower ileum
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mucosa
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mucosa
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activity is 20-30% greater in vitamin-A deficient animals than in the controls
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activity of enzyme in intestinal mucosa is higher after feeding with oleic acid or eicosapentanoic acid than with linoleic acid
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high expression, expression in small intestine is increased by vitamin A deficiency. Upregulation is suppressed by all-trans retinoic acid or 9-cis retinoic acid
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immunohistochemistry shows strong BCO1 immunoreactivity in the duodenum, particularly in Brunner's glands
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mucosa
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only marginal activity
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high levels of BCO mRNA
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high level, in distal and proximal tubular structures
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low expression
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high level, in distal and proximal tubular structures
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high level, in distal and proximal tubular structures
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diffuse distribution in the lobules, quantitative RT-PCR expression analysis and in situ hybridization
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high levels of BCO mRNA
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high level
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adult and embryonic, high Bco1 expression level
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adult and embryonic, high Bco1 expression level
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fetal
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high level
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high expression, expression is suppressed by all-trans retinoic acid
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BCO1 is highly expressed in hepatocytes, mucosal epithelium, hepatic stellate cells, and portal endothelial cells in liver
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fetal
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high level
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high expression, expression is increased by vitamin A deficiency. Upregulation is suppressed by all-trans retinoic acid or 9-cis retinoic acid
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left, fetal
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left, fetal
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low levels of BCO mRNA
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cells comprising the exocrine gland
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maternal
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maternal
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glandular cells
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low levels of BCO mRNA
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low levels of BCO mRNA
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epidermis
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epidermis
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epidermis
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mucosa
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high enzyme expression
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high enzyme expression
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mucosal and glandular cells
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low levels of BCO mRNA
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Leydig and Sertoli cells
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low expression
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Leydig and Sertoli cells
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Leydig and Sertoli cells
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additional information
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enzyme activity is similar in the duodenum, but pigmented animals have higher enzyme activity in the liver, eevnthough not high enough to prevent the storage of beta-carotene in adipose tissues
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additional information
no expression in lung
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no activity is detected in adult stomach tissue
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BCMO1 expression in the exocrine portion of the pancreas, epidermis of the skin, and ciliary body pigment epithelia and RPE of the eye
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additional information
quantitative reverse-transcriptase PCR enzyme expression analysis
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real-time quantitative RT-PCR enzyme expression analysis
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additional information
Bco1 tissue expression analysis
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additional information
retinoid levels in the developing liver and brain at mid-gestation, overview. BCO1-/- and wild-type female mice reveal a statistically significant decrease in retinol content in the heart, pancreas, spleen, eye and adipose tissue of the knockout females. Retinol concentrations are greater in the lungs of the BCO1-/- females compared to wild-type
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additional information
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Bco1 tissue expression analysis
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additional information
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BCMO1 expression in the exocrine portion of the pancreas, epidermis of the skin, and ciliary body pigment epithelia and RPE of the eye
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additional information
cellular expression and localization of BCO1 and BCO2 proteins in rat liver and intestine, immunohistochemic analysis, overview. BCO1 shows diffuse presence along epithelia with strong immunoreactivity in endothelial cells and in certain epithelial cells, possible intestinal retinoid storage cells
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additional information
quantitative real-time PCR expression analysis, no difference in the trophoblastic BCMO1 and 2 immunoreactivity in congenital diaphragmatic hernia, CDH, placenta compared to controls
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additional information
quantitative real-time PCR expression analysis, no difference in the trophoblastic BCMO1 and 2 immunoreactivity in congenital diaphragmatic hernia, CDH, placenta compared to controls
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additional information
tissue expression levels of the enzyme with and without dehydroepiandrosterone addition, overview
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additional information
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quantitative real-time PCR expression analysis, no difference in the trophoblastic BCMO1 and 2 immunoreactivity in congenital diaphragmatic hernia, CDH, placenta compared to controls
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additional information
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tissue expression levels of the enzyme with and without dehydroepiandrosterone addition, overview
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additional information
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BCMO1 expression in the exocrine portion of the pancreas, epidermis of the skin, and ciliary body pigment epithelia and RPE of the eye
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