1.13.11.62: linoleate 10R-lipoxygenase
This is an abbreviated version!
For detailed information about linoleate 10R-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.62
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1.13.11.62
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diol
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linoleic
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fumigatus
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dioxygenation
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heme
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oxylipins
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8r-dioxygenase
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nidulans
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aspergilli
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epoxidation
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unsaturated
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hydroperoxide
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epoxy
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tyr
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heterolytic
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9-hydroperoxy
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allene
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inter
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thiolate
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oxysporum
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antarafacial
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fusarium
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sporulation
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endemic
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human-pathogenic
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flavus
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mycotoxin
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scurf
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tritici
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magnaporthe
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solani
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grey
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graminearum
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verticillioides
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cyclooxygenase-1
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oryzae
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homolytic
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zymoseptoria
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8r-hydroperoxylinoleic
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hyphal
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synthesis
- 1.13.11.62
- diol
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linoleic
- fumigatus
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dioxygenation
- heme
- oxylipins
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8r-dioxygenase
- nidulans
-
aspergilli
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epoxidation
- unsaturated
- hydroperoxide
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epoxy
- tyr
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heterolytic
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9-hydroperoxy
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allene
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inter
-
thiolate
-
oxysporum
-
antarafacial
-
fusarium
-
sporulation
-
endemic
-
human-pathogenic
-
flavus
-
mycotoxin
-
scurf
-
tritici
-
magnaporthe
- solani
-
grey
-
graminearum
-
verticillioides
- cyclooxygenase-1
- oryzae
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homolytic
-
zymoseptoria
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8r-hydroperoxylinoleic
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hyphal
- synthesis
Reaction
Synonyms
(10R)-dioxygenase, 10R-dioxygenase, 10R-dioxygenase-epoxy alcohol synthase, 10R-DOX, 10R-DOX-EAS, PpoC, Psi-producing oxygenase
ECTree
1.13.11.62 linoleate 10R-lipoxygenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.13.11.62 - linoleate 10R-lipoxygenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-linolenate + O2
(8E,10R,12Z,15Z)-10-hydroperoxy-8,12,15-octadecatrienoate
i.e. (9Z,12Z,15Z)-octadeca-9,12,15-trienoate
-
-
?
alpha-linolenate + O2
10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate + 12(13)epoxy-10-hydroxy-(8E,15Z)-octadecadienoate
palmitoleate + O2
8-hydroperoxy-9(Z)-hexadecenoic acid
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low activity
-
-
?
alpha-linolenate + O2
(8E,10R,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate
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-
-
-
?
alpha-linolenate + O2
(8E,10R,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate
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moderate activity
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-
?
alpha-linolenate + O2
(8E,10R,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate
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-
-
-
?
alpha-linolenate + O2
(8E,10R,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate
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moderate activity
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-
?
alpha-linolenate + O2
10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate + 12(13)epoxy-10-hydroxy-(8E,15Z)-octadecadienoate
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-
-
?
alpha-linolenate + O2
10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate + 12(13)epoxy-10-hydroxy-(8E,15Z)-octadecadienoate
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-
-
?
linoleate + O2
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate
the enzyme is involved in biosynthesis of oxylipins
-
-
?
linoleate + O2
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate
abstraction of the pro-S hydrogen at C-8 and antarafacial dioxygenation at C-10 with double bond migration
-
-
?
linoleate + O2
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate
i.e. (9Z,12Z)-octadeca-9,12-dienoate. The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergilli
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-
?
linoleate + O2
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate
i.e. (9Z,12Z)-octadeca-9,12-dienoate. The wild-type enzyme forms 90% (8E,10R,12Z)-10-hydroperoxy-9,12-octadecadienoate, 10% (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate and small amounts of 12S(13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoic acid
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-
?
linoleate + O2
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate
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-
-
-
?
linoleate + O2
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate
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-
-
?
linoleate + O2
(8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate
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-
-
?
linoleate + O2
(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
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-
-
-
?
linoleate + O2
(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
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best substrate
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-
?
linoleate + O2
(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
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-
-
-
?
additional information
?
-
recombinant enzyme lacks hydroperoxide isomerase activity, but shows low epoxyalcohol synthase activity with biosynthesis of a novel oxylipin, 12S(13R)-epoxy-(10R)-hydroxy-18:1. The enzyme oxygenates 20:4n-6 (all-cis-5,8,11,14-eicosatetraenoic acid) i.e. by hydrogen abstraction at both C-13 and C-10 with formation of two nonconjugated and four cis-trans-conjugated hydroperoxyeicosatetraenoic acid
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-
?
additional information
?
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-
recombinant enzyme lacks hydroperoxide isomerase activity, but shows low epoxyalcohol synthase activity with biosynthesis of a novel oxylipin, 12S(13R)-epoxy-(10R)-hydroxy-18:1. The enzyme oxygenates 20:4n-6 (all-cis-5,8,11,14-eicosatetraenoic acid) i.e. by hydrogen abstraction at both C-13 and C-10 with formation of two nonconjugated and four cis-trans-conjugated hydroperoxyeicosatetraenoic acid
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-
?
additional information
?
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the enzyme produces both (8E,10R,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate and (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate from hempseed oil hydrolyzate
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-
?
additional information
?
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assay method optimization for the recombinant enzyme exprssed in Escherichia coli, overview
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-
?
additional information
?
-
-
the enzyme produces both (8E,10R,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate and (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate from hempseed oil hydrolyzate
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-
?
additional information
?
-
-
assay method optimization for the recombinant enzyme exprssed in Escherichia coli, overview
-
-
?
