1.13.11.60: linoleate 8R-lipoxygenase

This is an abbreviated version!
For detailed information about linoleate 8R-lipoxygenase, go to the full flat file.

Reaction

Synonyms

5,8-LDS, 5,8-linoleate diol synthase, 6,8-diol synthase, 6R,8R-linoleate diol synthase, 6R,8RLDS, 7,8-diol synthase, 7,8-LDS, 7,8-linoleate diol synthase, 8(R)-dioxygenase, 8,11-hydroperoxide isomerase, 8-DOX, 8R-dioxygenase, 8R-DOX, 8R-DOX-5,8-LDS, 8R-DOX-7,8-LDS, 8R-DOX-LDS, dioxygenase-cytochrome P450, DOX-CYP, EC 1.13.11.44, EGE82165, FOXB_09952, GLRG_10013, linoleate 7,8-LDS, linoleate 8,11-LDS, linoleate diol synthase, linoleic acid 8R-dioxygenase, ODH51007, orphan DOX-CYP, PpoA

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.60 linoleate 8R-lipoxygenase

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Results	in table
4	Activating Compound
486	AA Sequence
2	Application
17	Cloned(Commentary)
6	Cofactor
10	General Information
3	General Stability
11	IC50 Value
39	Inhibitors
28	kcat/KM [mM/s]
32	KM Value [mM]
1	Metals/Ions
9	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
43	Organism
1	Pathway
11	pH Optimum
1	pH Stability
2	pI Value
2	Posttranslational Modification
84	Protein Variants
8	Purification (Commentary)
1	Reaction
38	Reference
12	Source Tissue
11	Specific Activity [micromol/min/mg]
1	Storage Stability
135	Substrates and Products (Substrate)
14	Subunits
77	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Range [°C]
2	Temperature Stability [°C]
29	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.13.11.60 - linoleate 8R-lipoxygenase

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SYSTEMATIC NAME

IUBMB Comments

linoleate:oxygen (8R)-oxidoreductase

The enzyme contains heme [1,4]. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, which is subsequently isomerized by the C-terminal P-450 heme thiolate domain to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.5, 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase) [1]. The bifunctional enzyme from Gaeumannomyces graminis also catalyses the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, but its second domain isomerizes it to (7S,8S,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.6, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase) [4].