1.13.11.57: gallate dioxygenase
This is an abbreviated version!
For detailed information about gallate dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.57
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1.13.11.57
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4,5-dioxygenase
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protocatechuate
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sphingomonas
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paucimobilis
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syringate
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ligab
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3-o-methylgallate
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vanillate
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4,5-cleavage
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tetrahydrofolate-dependent
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o-demethylase
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tetrahydrofolate
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extradiol
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4-oxalomesaconate
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h4folate
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20-oxidases
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gibberellin
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sphingobium
- 1.13.11.57
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4,5-dioxygenase
- protocatechuate
-
sphingomonas
- paucimobilis
- syringate
- ligab
- 3-o-methylgallate
- vanillate
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4,5-cleavage
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tetrahydrofolate-dependent
- o-demethylase
- tetrahydrofolate
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extradiol
- 4-oxalomesaconate
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h4folate
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20-oxidases
- gibberellin
- sphingobium
Reaction
Synonyms
DesB, GA dioxygenase, GALA, gallate 3,4-dioxygenase
ECTree
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results (Substrates Products
Substrates Products on EC 1.13.11.57 - gallate dioxygenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3,4,5-trihydroxybenzoate + O2
(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
DesB has strict substrate specificity for 3,4,5-trihydroxybenzoate (gallate). Biochemical and structural study show the substrate recognition and catalytic mechanisms of extradiol dioxygenase DesB. Mutational analysis reveals that His124 and His192 in the active site are essential to the catalytic reaction of the extradiol dioxygenase DesB. His124, which interacts with OH(4) of the bound gallate, seems to contribute to proper positioning of the substrate in the active site. His192, which is located close to OH (3) of the gallate, is likely to serve as the catalytic base. Glu377' interacts with OH(5) of the gallate and seems to play a critical role in the substrate specificity
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-
?
gallate + O2
(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
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gallate is also namend gallic acid or 3,4,5-trihydroxybenzoic acid
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-
?
gallate + O2
(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate
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gallate is also namend gallic acid or 3,4,5-trihydroxybenzoic acid
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-
?
gallate + O2
(2E,4E)-4-(carboxymethylidene)-2-hydroxypent-2-enedioate
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-
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?
gallate + O2
(2E,4E)-4-(carboxymethylidene)-2-hydroxypent-2-enedioate
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-
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?
gallate + O2
4-oxalomesaconate
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the substrate specificity is very restricted toward gallate
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-
?
gallate + O2
4-oxalomesaconate
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the substrate specificity is very restricted toward gallate
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-
?
additional information
?
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no activity with protocatechuate, catechol, resorcinolate, resorcinol, gentisate, hydroquinone, pyrogallol, methylgallate, or syringate
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-
?
additional information
?
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no activity with protocatechuate, catechol, resorcinolate, resorcinol, gentisate, hydroquinone, pyrogallol, methylgallate, or syringate
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-
?
additional information
?
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no activity with protocatechuate, 3-O-methylgallate, gentisate, 2,3-dihydroxybiphenyl, 4-methylcatechol, 2,3-dihydroxybenzoate, and methylgallate
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-
?
additional information
?
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no activity with protocatechuate, 3-O-methylgallate, gentisate, 2,3-dihydroxybiphenyl, 4-methylcatechol, 2,3-dihydroxybenzoate, and methylgallate
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-
?
additional information
?
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no activity with protocatechuate, 3-O-methylgallate, gentisate, 2,3-dihydroxybiphenyl, 4-methylcatechol, 2,3-dihydroxybenzoate, and methylgallate
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-
?
