1.13.11.52: indoleamine 2,3-dioxygenase

This is an abbreviated version!
For detailed information about indoleamine 2,3-dioxygenase, go to the full flat file.

Reaction

Synonyms

31854, BRAFLDRAFT_126354, CG5163, EC 1.13.1.12, hIDO, hIDO1, hTDO, IDO, IDO-1, IDO-2, IDO-I, IDO-II, IDO-III, IDO-IV, IDO1, IDO2, INDO, INDOL1, indolamine 2,3-dioxygenase, indole 2,3-dioxygenase, indoleamine 2, 3-dioxygenase, indoleamine 2,3 dioxygenase, indoleamine 2,3-dioxygenase, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein, indoleamine-2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase, L-tryptophan 2,3-dioxygenase, L-tryptophan pyrrolase, mIDO, oxygenase, tryptophan 2,3-di-, proto-IDO, proto-indoleamine 2,3-dioxygenase, superoxygenase, TDO, TDO2, TioF, TO, TRPO, Tryptamin 2,3-dioxygenase, tryptamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase, tryptophan dioxygenase, tryptophan oxygenase, tryptophan peroxidase, tryptophan pyrrolase, tryptophan-2,3-dioxygenase, tryptophanase, v1g244579, Vermilion protein

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.52 indoleamine 2,3-dioxygenase

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Results	in table
73	Activating Compound
71	AA Sequence
32	Application
1	CAS Registry Number
89	Cloned(Commentary)
161	Cofactor
14	Crystallization (Commentary)
3561	Disease/ Diagnostics
31	Expression
98	General Information
6	General Stability
488	IC50 Value
906	Inhibitors
27	kcat/KM [mM/s]
94	Ki Value [mM]
209	KM Value [mM]
16	Localization
24	Metals/Ions
53	Molecular Weight [Da]
207	Natural Substrates/ Products (Substrates)
337	Organism
3	Oxidation Stability
9	Pathway
155	PDB ID
44	pH Optimum
7	pH Range
6	pH Stability
3	pI Value
5	Posttranslational Modification
48	Protein Variants
78	Purification (Commentary)
8	Reaction
4	Reaction Type
322	Reference
390	Source Tissue
108	Specific Activity [micromol/min/mg]
9	Storage Stability
501	Substrates and Products (Substrate)
48	Subunits
322	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
11	Temperature Stability [°C]
111	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.13.11.52 - indoleamine 2,3-dioxygenase

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SYSTEMATIC NAME

IUBMB Comments

D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase [1]. It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver [2]. While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan [2,6]. Superoxide radicals can replace O2 as oxygen donor [4,7].