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1.13.11.52: indoleamine 2,3-dioxygenase

This is an abbreviated version!
For detailed information about indoleamine 2,3-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.52

Reaction

D-tryptophan
+
O2
=
N-formyl-D-kynurenine

Synonyms

31854, BRAFLDRAFT_126354, CG5163, EC 1.13.1.12, hIDO, hIDO1, hTDO, IDO, IDO-1, IDO-2, IDO-I, IDO-II, IDO-III, IDO-IV, IDO1, IDO2, INDO, INDOL1, indolamine 2,3-dioxygenase, indole 2,3-dioxygenase, indoleamine 2, 3-dioxygenase, indoleamine 2,3 dioxygenase, indoleamine 2,3-dioxygenase, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein, indoleamine-2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase, L-tryptophan 2,3-dioxygenase, L-tryptophan pyrrolase, mIDO, oxygenase, tryptophan 2,3-di-, proto-IDO, proto-indoleamine 2,3-dioxygenase, superoxygenase, TDO, TDO2, TioF, TO, TRPO, Tryptamin 2,3-dioxygenase, tryptamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase, tryptophan dioxygenase, tryptophan oxygenase, tryptophan peroxidase, tryptophan pyrrolase, tryptophan-2,3-dioxygenase, tryptophanase, v1g244579, Vermilion protein

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.52 indoleamine 2,3-dioxygenase

Source Tissue

Source Tissue on EC 1.13.11.52 - indoleamine 2,3-dioxygenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
detectable immunohistochemically from day 6
Manually annotated by BRENDA team
-
marrow stromal cell or mesenchymal stem cells (MSC)
Manually annotated by BRENDA team
-
from humans suffering from inflammatory neurological disorders exhibit increased IDO activity
Manually annotated by BRENDA team
-
very irregular activity
Manually annotated by BRENDA team
consistently expresses the enzyme at low levels. Exposure to UV-light leads to a dose-responding upregulation. Overexpression of indoleamine-pyrrole 2,3-dioxygenase could reduce apoptosis significantly following UV-B irradiation
Manually annotated by BRENDA team
-
IDO-competent cells exhibit attributes of B cells as well as dendritic cells
Manually annotated by BRENDA team
-
cells grown in a medium containing L-tryptophan as the sole carbon, nitrogen, and energy source
Manually annotated by BRENDA team
-
extravillous
Manually annotated by BRENDA team
-
despite suppression by progesterone, indoleamine 2,3-dioxygenase expression in endometrial stromal cells may increase during decidualization due to stimulation by interferon-gamma secreted by infiltrating leukocytes
Manually annotated by BRENDA team
-
of uterine endometrium and cervix
Manually annotated by BRENDA team
-
mature granule cells of the adult mouse dentate gyrus
Manually annotated by BRENDA team
-
primary hepatocyte
Manually annotated by BRENDA team
-
i.e. human umbilical vein endothelial cell, express little indoleamine 2,3-dioxygenase, which is poorly upregulated upon activation (except by mycoplasma)
Manually annotated by BRENDA team
-
in HUVEC cells the enzyme is upregulated by incubation with cytokines or in mycoplasma-infected cells. Inhibition of indoleamine 2,3-dioxygenase improves ability of HUVEC cells to stimulate T-cell proliferation
Manually annotated by BRENDA team
-
Langerhans cells possess an immunoregulatory function in promoting T cell tolerance by production of IDO
Manually annotated by BRENDA team
-
enzyme activity is detected in all lenses ranging from 26 to 80 years and there are no clear relationship of IDO activity with age
Manually annotated by BRENDA team
-
anterior and bow region
Manually annotated by BRENDA team
-
IFNgamma-primed
Manually annotated by BRENDA team
-
IDO-competent cells are present in spleens of B-cell-deficient mice
Manually annotated by BRENDA team
-
peritumoral infiltrate
Manually annotated by BRENDA team
-
premetamorphic stage
Manually annotated by BRENDA team
low level expression
Manually annotated by BRENDA team
highest expression in liver and trunk kidney
Manually annotated by BRENDA team
-
epithelium
Manually annotated by BRENDA team
additional information