1.13.11.45: linoleate 11-lipoxygenase
This is an abbreviated version!
For detailed information about linoleate 11-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.45
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1.13.11.45
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oxylipins
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graminis
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bis-allylic
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gaeumannomyces
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suprafacial
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take-all
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antarafacial
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atlox2
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lipoxygenation
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hydroperoxy
- 1.13.11.45
- oxylipins
- graminis
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bis-allylic
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gaeumannomyces
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suprafacial
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take-all
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antarafacial
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atlox2
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lipoxygenation
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hydroperoxy
Reaction
Synonyms
13 R -MnLOX, 13R-MnLOX, Cg-MnLOX, CspLOX2, Fo-MnLOX, linoleate dioxygenase, lipoxygenase 2, LOX-1, manganese lipoxygenase, manganese LOX, MGG_08499, Mn-LO, Mn-LOX, MnLOX, Mo-MnLOX
ECTree
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Reaction
Reaction on EC 1.13.11.45 - linoleate 11-lipoxygenase
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linoleate + O2 = (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate
mechanism via suprafacial migration of O2
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linoleate + O2 = (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate
reaction mechanism, tail-first model with rearrangement at C13 at the end of lipoxygenation, influenced by double bond configuration and the chain length of fatty acids, overview
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linoleate + O2 = (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate
the LOX reaction is always catalyzed at a 1Z,4Z-pentadiene system of a polyunsaturated fatty acid. In the initial step, a hydrogen atom is abstracted from the central bis-allylic methylene group by the non-heme iron or in few cases manganese in the active site. During this rate-limiting step, Fe(III) is reduced to Fe(II) in the former case and a substrate radical is formed which rapidly delocalizes over the five carbon unit. Addition of dioxygen yields a peroxyl radical, which is finally reduced to the hydroperoxide product