1.13.11.40: arachidonate 8-lipoxygenase
This is an abbreviated version!
For detailed information about arachidonate 8-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.40
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1.13.11.40
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lipoxygenases
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coral
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allene
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plexaura
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homomalla
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8r-hpete
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epidermis-type
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whip
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12r-lox
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8-hydroxyeicosatetraenoic
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medicine
- 1.13.11.40
- lipoxygenases
-
coral
-
allene
-
plexaura
- homomalla
-
8r-hpete
-
epidermis-type
-
whip
- 12r-lox
-
8-hydroxyeicosatetraenoic
- medicine
Reaction
Synonyms
8(R)-lipoxygenase, 8-lipoxygenase, 8-LOX, 8R-lipoxygenase, 8R-LOX, 8S-lipoxygenase, 8S-LOX, allene oxide synthase-lipoxygenase protein, arachidonic acid C-8 lipoxygenase, eicosapentaenoic 8R-lipoxygenase, LOX-1, More
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Metals Ions
Metals Ions on EC 1.13.11.40 - arachidonate 8-lipoxygenase
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Ca2+
Fe2+
the catalytic iron in 8R-LOX is positioned by three invariant His384, His389, and His570 side chains and the terminal main chain. Fe2+ sits in the base of a large U-shaped cavity, positioned by invariant Leu385 on one side, and the iron and His384 and His389 on the other. Leu385 and the catalytic iron cradle the base of the U
Iron
during the hydrogen abstraction step, the hydroxyl group bound to the metal center activates the C-H bond of the double-allylic carbon center of the substrate that leads to the formation of a radical center at the substrate
Ca2+
has three Ca2+ binding sites flanked by putative membrane insertion loops in the C2-like domain