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1.13.11.40: arachidonate 8-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 8-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.40

Reaction

arachidonate
+
O2
=
(5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate

Synonyms

8(R)-lipoxygenase, 8-lipoxygenase, 8-LOX, 8R-lipoxygenase, 8R-LOX, 8S-lipoxygenase, 8S-LOX, allene oxide synthase-lipoxygenase protein, arachidonic acid C-8 lipoxygenase, eicosapentaenoic 8R-lipoxygenase, LOX-1, More

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.40 arachidonate 8-lipoxygenase

KM Value

KM Value on EC 1.13.11.40 - arachidonate 8-lipoxygenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.039
(15S)-hydroperoxyeicosatetraenoic acid
-
in 50 mM sodium phosphate buffer, pH 7.4, at 25°C
0.015
(15S)-hydroxyeicosatetraenoic acid
-
in 50 mM sodium phosphate buffer, pH 7.4, at 25°C
0.0021
(8R)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid
-
in 50 mM sodium phosphate buffer, pH 7.4, at 25°C
0.0057
(8S)-hydroxyeicosatetraenoic acid
-
in 50 mM sodium phosphate buffer, pH 7.4, at 25°C
0.008 - 0.135
arachidonate
0.0012 - 0.008
arachidonic acid
additional information
additional information
substrate inhibition steady state kinetics
-