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metabolism
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the 2,3-DHBP dioxygenase is a key enzyme in the polychlorinated biphenyl degradation pathway
metabolism
BphC is the key enzyme for polychlorobiphenyl transformation
metabolism
BphC1 plays a role in the upstream and downstream metabolic pathways of biphenyl, overview
metabolism
BphC2 might play a supplementary role and contribute more to the upstream than to the downstream pathway of biphenyl, overview
metabolism
BphC3 plays a role in the upstream and downstream metabolic pathways of biphenyl, overview
metabolism
2,3-dihydroxybiphenyl 1,2-dioxygenase is an extradiol-type dioxygenase involved in third step of biphenyl degradation pathway
metabolism
tThe HOO radical species is the reactive oxygen species responsible for the attack of 2,3-dihydroxybiphenyl. The first step in proton-coupled electron transfer is the rate-determining step with a potential energy barrier of 17.2 kcal/mol, close to the experimental value of 14.7 kcal/mol. Residue His194 acts as an acid-base catalyst to deprotonate the hydroxyl group of 2,3-dihydroxybiphenyl at an early stage, then stabilizes the negative charge on the dioxygen group, and finally promotes the semialdehyde product formation as a proton donor
metabolism
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2,3-dihydroxybiphenyl 1,2-dioxygenase is an extradiol-type dioxygenase involved in third step of biphenyl degradation pathway
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metabolism
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BphC3 plays a role in the upstream and downstream metabolic pathways of biphenyl, overview
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metabolism
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BphC1 plays a role in the upstream and downstream metabolic pathways of biphenyl, overview
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metabolism
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BphC2 might play a supplementary role and contribute more to the upstream than to the downstream pathway of biphenyl, overview
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physiological function
2,3-dihydroxybiphenyl-1,2-dioxygenase plays an important role in the degradation of polychlorinated biphenyls
physiological function
BphC catalyzes the ring cleavage of 2,3-dihydroxybiphenyl during biphenyl/polychlorobipheny degradation process
physiological function
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strain is able to degrade a solution containing benzene, toluene, ethylbenzene, and xylene at 7% NaCl (w/v) and pH 9
physiological function
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the strain is able to completely degrade 280 microM of phenanthrene, 40% of 50 microM pyrene or 28% of 40 microM benzo[a]pyrene, each supplemented in M9 medium, within 7 days. The strain harbors genes which code for 2,3-dihydroxybiphenyl 1,2-dioxygenase (bphC), 4-nitrophenol 2-monooxygenase component B (npcB) as well as oxygenase component (nphA1), 4-hydroxybenzoate 3-monooxygenase (phbH), extradiol dioxygenase (edo), and naphthalene dioxygenase (ndo)
physiological function
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the strain is able to consume diphenyl ether and biphenyl from heat transfer fluid of thermo-solar plants (about 90% of total heat transfer fluid consumed after 1 day). The strain almost completely degrades 2,000 ppm heat transfer fluid after 5-day culture, and tolerates and grows in the presence of 150,000 ppm heat transfer fluid. When either biphenyl or diphenyl ether is used as sole carbon source, degradation is also effective
physiological function
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the strain is able to consume diphenyl ether and biphenyl from heat transfer fluid of thermo-solar plants (about 90% of total heat transfer fluid consumed after 1 day). The strain almost completely degrades 2,000 ppm heat transfer fluid after 5-day culture, and tolerates and grows in the presence of 150,000 ppm heat transfer fluid. When either biphenyl or diphenyl ether is used as sole carbon source, degradation is also effective
physiological function
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the strain is able to consume diphenyl ether and biphenyl from heat transfer fluid of thermo-solar plants (about 90% of total heat transfer fluid consumed after 1 day). The strain almost completely degrades 2,000 ppm heat transfer fluid after 5-day culture, and tolerates and grows in the presence of 150,000 ppm heat transfer fluid. When either biphenyl or diphenyl ether is used as sole carbon source, degradation is also effective
physiological function
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the strain is able to consume diphenyl ether and biphenyl from heat transfer fluid of thermo-solar plants (about 90% of total heat transfer fluid consumed after 1 day). The strain almost completely degrades 2,000 ppm heat transfer fluid after 5-day culture, and tolerates and grows in the presence of 150,000 ppm heat transfer fluid. When either biphenyl or diphenyl ether is used as sole carbon source, degradation is also effective
physiological function
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2,3-dihydroxybiphenyl-1,2-dioxygenase plays an important role in the degradation of polychlorinated biphenyls
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additional information
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analysis of the interaction between BphC_LA-4 and catecholic substrates by homology modeling and molecular docking, model of the BphC_LA-4-catechol complex, overview. BphC_LA-4 presents lower binding affinity towards 4-methylcatechol in comparison with 3-methylcatechol and catechol. A BphC_LA-4 enzyme electrode prepared by SiO2 sol-gel shows good response to all these three catecholic compounds
additional information
enzyme homology modeling, overview
additional information
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modeling of substrates into the active site of the enzyme using BphC from Burkholderia xenovorans strain LB400, which has 74% identity, as the templates, molecular docking studies, overview
additional information
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enzyme structure homology modeling, overview
additional information
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enzyme structure molecular simulation, overview
additional information
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modeling of substrates into the active site of the enzyme using BphC from Burkholderia xenovorans strain LB400, which has 74% identity, as the templates, molecular docking studies, overview
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additional information
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enzyme structure molecular simulation, overview
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additional information
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analysis of the interaction between BphC_LA-4 and catecholic substrates by homology modeling and molecular docking, model of the BphC_LA-4-catechol complex, overview. BphC_LA-4 presents lower binding affinity towards 4-methylcatechol in comparison with 3-methylcatechol and catechol. A BphC_LA-4 enzyme electrode prepared by SiO2 sol-gel shows good response to all these three catecholic compounds
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